Growth inhibitory retinoid effects after recruitment of retinoid X receptor beta to the retinoic acid receptor beta promoter

International Journal of Cancer. Journal International Du Cancer
Belamy CheungG M Marshall

Abstract

Nuclear retinoid receptors mediate retinoid effects through tissue-specific, ligand-receptor interactions and subsequent transcriptional regulation of secondary target genes. Retinoic acid receptor beta (RARbeta) is itself a retinoid target gene with a retinoic acid response element (betaRARE) in the 5' untranslated region of the RARbeta2 gene. Altered transcriptional regulation of RARbeta may play a role in human carcinogenesis and the retinoid-responsiveness of malignant cells. Here we used retinoid X receptor-specific antibodies in electrophoretic mobility shift assays to show that the retinoid X receptor beta (RXRbeta) protein was recruited to the betaRARE, after retinoid treatment of retinoid-sensitive neuroblastoma (NB), lung and breast cancer cell lines, but not retinoid-resistant lung and breast cancer cell lines. RXRbeta selectively enhanced retinoid-induced transcriptional activation of the betaRARE. Stable overexpression of RXRalpha and RXRbeta in NB cells resulted in marked growth inhibition and cell death, which increased after retinoid treatment. However, only proteins from the RXRbeta transfectants exhibited specific RXRbeta binding to the betaRARE in vitro and in vivo, enhanced histone acetylation and increased ...Continue Reading

References

Apr 28, 1988·Nature·N BrandA Dejean
Sep 1, 1982·Molecular and Cellular Biology·C M GormanB H Howard
Nov 1, 1994·Developmental Biology·C MendelsohnP Chambon
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B HouleW E Bradley
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T LufkinP Chambon
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Dec 15, 1995·Cell·D J Mangelsdorf, R M Evans
Sep 5, 1996·Nature·D ChakravartiR M Evans
Mar 19, 1997·Journal of the National Cancer Institute·P E LovatC P Redfern
Nov 5, 1997·Journal of Pediatric Hematology/oncology·J G GurneyL L Robison
Jun 24, 1999·Journal of the National Cancer Institute·E PicardJ M Vignaud
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·N J McKennaB W O'Malley
Feb 26, 2000·Carcinogenesis·M B Sporn, N Suh
May 18, 2000·Journal of the National Cancer Institute·M WidschwendterC Marth
Jun 9, 2000·Annual Review of Physiology·J Zhang, M A Lazar
Aug 17, 2000·Journal of the National Cancer Institute·A K VirmaniA F Gazdar
Jun 9, 2001·Journal of Neuroscience Research·U Reimann-PhilippP Grammas
Jul 17, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·T NakayamaT Shiraishi
Mar 21, 2002·Nature Reviews. Cancer·L Altucci, H Gronemeyer

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Citations

Jan 8, 2009·British Journal of Cancer·A BohlkenG M Marshall
Feb 3, 2005·Physiological Genomics·Paul G GiresiSusan C Kandarian
Jul 14, 2005·British Journal of Cancer·T LiuG M Marshall
Apr 26, 2006·The Journal of Biological Chemistry·Belamy B CheungGlenn M Marshall
Jul 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Murat BingulDavid StC Black

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