Growth, insulin-like growth factor I (IGF-I), and IGF-binding proteins 1 and 3 in children with severe liver disease before and after liver transplantation: a longitudinal and cross-sectional study

Pediatric Research
F BuziM A Preece

Abstract

We aimed to study the growth and growth factors of children with liver disease before and after liver transplantation (LT). Three observation intervals: 1) before LT (preLT), 2) after LT on daily prednisone treatment (dP), and 3) on alternate day prednisone (adP). A longitudinal study (LS) involved 17 infants (9 male) aged 0.73-2.38 y at LT; mean (+/- SD) height (Ht) SD score (SDS) at LT was -2.02 (+/- 1.25). In a cross-sectional study, there were 123 children (73 male) aged 0.16-14.88 y (mean 3.72 y). IGF-I and IGF binding proteins (BP) 1 and 3 were measured at the same intervals. The results were, for LS, preLT height velocity (HV) SDS (X +/- SD -0.8+/-1.4) lower (p < 0.01) than adP-HV SDS (3.1+/-1.8) but not different from dP-HV SDS (-1.0+/-1.9). For the cross-sectional study, dP-Ht SDS (X+/-SD -1.94+/-1.31) lower (p < 0.001) than preLT-Ht SDS (-1.03+/-1.06) and adP-Ht SDS (-0.98+/-1.20). Parental target SDS was not different from adP-Ht SDS. (Similar observations were made in the LS.) The dP- sitting height (SH) and subischial leg length (SLL) SDS were significantly lower than both preLT- and adP-SH SDS and SLL SDS (p = 0.02 and 0.002, respectively). There was a significant improvement of head circumference SDS and arm circ...Continue Reading

References

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Citations

Aug 4, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·E F De PaloU Cillo
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Apr 25, 2000·Journal of Pediatric Gastroenterology and Nutrition·V RamaccioniW J Klish
Oct 16, 1999·Archives of Disease in Childhood·R Bjarnason, M O Savage
Dec 14, 2011·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Edyta KryskiewiczRoman S Lorenc
Jun 4, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maximilian JaraMartin Stockmann
Jul 31, 2008·Journal of Pediatric Gastroenterology and Nutrition·Rene ScheenstraPieter J J Sauer
Apr 27, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marco BassanelloUmberto Cillo
Jul 14, 2020·Journal of Neuroendocrinology·Melody L Allensworth-JamesGwen V Childs
Apr 25, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Marion KesslerBina Shah

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