Growth kinetics of Dioscorea deltoidea and Catharanthus roseus in batch culture

Biotechnology and Bioengineering
D DrapeauC R Wilke

Abstract

Sugar-limited batch growth of Dioscorea deltoidea and Catharanthus roseus plant cell cultures was studied in a 14-L stirred tank fermentor. With dissolved oxygen concentration monitored and maintained at nonlimiting levels, growth rates and ratios of dry weight to fresh weight were found to be strongly influenced by sugar concentration. Linear relationships between respiration rate and growth rate were observed, and respiration rate was found to drop to a maintenance level after sugar had been fully depleted from the medium. Diosgenin biosynthesis by D. deltoidea was shown to be independent of growth rate. Ajmalicine biosynthesis in C. roseus was negligible during sugar-limited growth but was induced by inoculation into an 80-g/L glucose solution.

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Citations

Dec 5, 1989·Biotechnology and Bioengineering·C M Bailey, H Nicholson
Feb 5, 1990·Biotechnology and Bioengineering·C M Bailey, H Nicholson
Mar 5, 1990·Biotechnology and Bioengineering·P J Westgate, A H Emery
Mar 5, 1993·Biotechnology and Bioengineering·R BhadraJ V Shanks
Sep 5, 1995·Biotechnology and Bioengineering·I AnantaP M Doran
Mar 1, 1992·World Journal of Microbiology & Biotechnology·J J ZhongT Yoshida
Oct 11, 2003·Biotechnology Advances·S R Rao, G A Ravishankar
Nov 6, 2004·Nature Biotechnology·Stephan HellwigRainer Fischer
Jul 20, 1995·Biotechnology and Bioengineering·M F PépinF Cormier
Dec 5, 1987·Biotechnology and Bioengineering·D DrapeauC R Wilke
Jan 15, 1989·Biotechnology and Bioengineering·G C Frazier
Oct 20, 1989·Biotechnology and Bioengineering·G H RobertsonN Goodman

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