PMID: 2113919Jul 1, 1990Paper

Growth medium-independent genetic competence mutants of Bacillus subtilis

Journal of Bacteriology
David Dubnau, M Roggiani

Abstract

The development of competence in Bacillus subtilis is normally dependent on the growth medium. Expression of late competence genes occurs in glucose-minimal salts-based media but not in complex media. Expression is also inhibited when glutamine is added to competence medium and when glycerol is substituted for glucose. Mutations have been identified in two regulatory loci, mecA and mecB, which render competence development independent of these variables. Although in mec mutants the expression of late competence genes, as well as of competence itself, occurred in all media tested, this expression was still growth stage regulated. Thus at least some forms of medium-dependent and growth stage-specific regulation are genetically separable. One of the mecB mutations (mecB31) conferred oligosporogenicity. The mecB mutations were tightly linked by transformation to rif, lpm, and std markers and were located between rif-2103 and cysA14. The mecA42 mutant was linked by transduction to argC4.

References

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Citations

Jan 1, 1991·Molecular Microbiology·D Dubnau
Jul 21, 2009·Biotechnology Journal·Pinar KocabaşTunçer H Ozdamar
Jul 28, 2017·Frontiers in Molecular Biosciences·Alexander K W ElsholzKürşad Turgay
Jun 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B A Lazazzera, A D Grossman
Mar 10, 2006·The EMBO Journal·Janine KirsteinKürşad Turgay
Sep 22, 2009·The Journal of Biological Chemistry·Ziqing MeiYigong Shi
Dec 20, 2005·The Journal of Biological Chemistry·Fredrik I AnderssonAdrian K Clarke
Jul 18, 2009·Nature Reviews. Microbiology·Janine KirsteinKürşad Turgay
Feb 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tilman SchlothauerKürşad Turgay
Apr 13, 2000·Journal of Bacteriology·S AshikagaF Kawamura
Jun 22, 2006·Journal of Bacteriology·Marcus MiethkeUlf Gerth
Mar 27, 2002·Journal of Bacteriology·Marjan PersuhDavid Dubnau
Apr 1, 1997·Microbiology·EIke KrügerMichael Hecker
Apr 1, 1996·Trends in Genetics : TIG·J M Solomon, A D Grossman
Oct 1, 1996·Journal of Bacteriology·P Serror, A L Sonenshein
Jun 1, 1994·Research in Microbiology·D DubnauY Weinrauch
Jul 1, 1990·Journal of Bacteriology·M RoggianiD Dubnau
Sep 1, 1991·Microbiological Reviews·D Dubnau

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