Growth of artificially fed infant rats: effect of supplementation with insulin-like growth factor I

The American Journal of Physiology
A F PhilippsO Koldovsky

Abstract

Insulin-like growth factor I (IGF-I), a potent mitogenic peptide, is present in considerable quantities in most mammalian milks, but its importance for the neonate is unknown. To test the hypothesis that milk-borne IGF-I is an important factor in the regulation of neonatal growth, as well as that of the gastrointestinal tract, rat pups were fed a rat milk substitute (RMS) devoid of growth factors via gastrostomy. These animals were compared with those given RMS supplemented with recombinant human IGF-I added at a concentration of 500 ng/ml. Animals given RMS + IGF-I gained mere weight than controls, although skeletal growth as represented by elongation of the tail was no different. Animals fed RMS + IGF-I had increased brain and liver wet weights as well as increased liver and small intestine protein contents. Serum IGF-I concentrations in the IGF-I-supplemented group were more than twofold above RMS controls and were similar to dam-fed rat pups. Semiquantification of serum IGF-binding proteins (IGFBP) in these animals documented that in IGF-I-supplemented pups the amount of 38- to 40-kDa molecular mass IGFBP species was also greater than in RMS controls. The rate of migration of enterocytes from crypts in duodenum and proximal...Continue Reading

Citations

Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert H LaneAnthony F Philipps
May 24, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth M DahlyDenise M Ney
Oct 4, 2000·Physiological Reviews·J Pácha

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