Growth of cultured cells from patients with Fanconi anemia

Journal of Cellular Physiology
E Elmore, M Swift

Abstract

Fibroblast cultures derived from skin biopsies of patients with Fanconi anemia had doubling times (mean of five lines: 30.3 +/- 0.2 hours) significantly longer than randomly selected normal controls (mean of nine lines: 22.9 +/- 0.4 hours). Control cultures grew more slowly in the enriched media RPMI 1640 and McCoy's 5A than in MEM; while a culture from a patient with Fanconi anemia grew more slowly only in McCoy's 5A. Differences in growth characteristics between Fanconi anemia and normal cell cultures may be useful in analyzing the metabolic error determined by the Fanconi anemia gene.

References

Jan 1, 1972·Experimental Cell Research·C A RyanH L Nadler
Dec 1, 1969·Journal of Cellular Physiology·G S Merz, J D Ross
Sep 1, 1966·Annals of Internal Medicine·M R Swift, K Hirschhorn
Jun 1, 1966·Experimental Cell Research·A Macieira-CoelhoL Philipson

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Citations

Feb 1, 1981·Mutation Research·J H FrazelleM Swift
Sep 1, 1986·Mutation Research·G Duckworth-RysieckiM Buchwald
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C Diatloff-ZitoE Moustacchi
Jan 1, 1980·British Journal of Haematology·G Daneshbod-SkibbaN T Shahidi
Jan 1, 1990·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·F BerniniR Fumagalli
Feb 1, 1991·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A CorsiniR Paoletti
Nov 1, 1990·Somatic Cell and Molecular Genetics·M Z ZdzienickaJ W Simons
Nov 1, 1979·Journal of Cellular Physiology·R WeksbergL Siminovitch
Nov 1, 1976·Journal of Cellular Physiology·E Elmore, M Swift
Dec 26, 2007·Pathology Oncology Research : POR·Stephen G GrantJean J Latimer
Jan 1, 1987·American Journal of Medical Genetics. Supplement·N T Shahidi
Sep 1, 1984·Jinrui idengaku zasshi. The Japanese journal of human genetics·K Ohno, K Takeshita
May 1, 1981·British Journal of Haematology·B R GreenbergJ Taplett

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