PMID: 2479231Jan 1, 1989Paper

Growth of keratinolytic and non-keratinolytic fungi on human hairs. A physiological study.

Acta Universitatis Palackianae Olomucensis Facultatis Medicae
Jiri Kunert

Abstract

Twenty-six keratinolytic fungi (16 dermatophytes and 10 soil species) and sixteen non-keratinolytic fungi were cultivated on sterile human hair in a mineral solution. With keratinolytic fungi, the loss in total dry weight (hair + mycelium) reached 7.6 up to 24.2% after 60 days of cultivation. Peptidic (Lowry-positive) substances accumulated in the medium and pH of the medium gradually increased, often over pH 8. Excess of sulfur contained in the substrate was excreted back into the medium predominantly in the form of inorganic sulfate. Moreover, sulfite was produced that cleaved disulfide bonds of the substrate giving rise to S-sulfocysteine; soluble products of keratin degradation in the medium contained 2.1 to 6.5% of that substance. This supports the presumption that sulfitolysis of disulfide bonds is a key reaction of keratinolysis in fungi. Statistically significant correlations were observed between substrate degradation and medium alkalinization, as well as the contents of peptidic substances, sulfate, and S-sulfocysteine. The correlation was highest with sulfate content and least significant with peptidic substances. Non-keratinolytic fungi mostly grew on the hair but did not cause a gravimetrically measurable loss of t...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.