PMID: 518297Jan 1, 1979Paper

Growth of measles virus in continuous cell lines derived from the nervous tissues of human and rat

Archives of Virology
K KobuneA Shishido

Abstract

Growth of two measles virus strains, the TYCSA and CAM, was compared in three continuous cell lines derived from the nervous tissues, human neuroblastoma IMR-32, human glioma 118MGC, and rat glioma C-6. The two human neural cells were shown to support the growth of both measles virus strains as efficiently as in the non-neural Vero cells. Different types of cytopathic effect (CPE) between the two virus strains were noticed in IMR-32 cells; the CAM strain induced strand-forming type CPE and the TYCSA strain giant-cell type CPE. As a difference of growth pattern between IMR-32 and 118MGC cells, virus antigen was demonstrated in both the nucleus and cytoplasm of 118MGC cells whereas virus antigen was present only in the cytoplasm of IMR-32 cells. In contrast to the productive infection in human neural cells, growth of both virus strains was restricted in rat glioma C-6 cells without showing CPE although the prolonged presence of virus antigens was demonstrated by the immunofluorescent technique.

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Citations

Dec 1, 1988·Journal of Neuroimmunology·K RöserK Mannweiler
Jan 1, 1984·Microbiology and Immunology·M SakaguchiK Yamanouchi
Jul 27, 2001·Pediatric Annals·J L Kastner, B G Gellin
Jan 1, 1985·Archives of Dermatological Research·A RinneP Bohley
Feb 10, 2012·FEMS Microbiology Reviews·Diane E GriffinChien-Hsiung Pan
Oct 1, 1991·Microbial Pathogenesis·D L Krah
Dec 1, 1991·Experimental Cell Research·K RöserK Mannweiler

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