PMID: 5581294Mar 1, 1971Paper

Growth of metastases from P-388 sarcoma in the rat followig whole body irradiation

British Journal of Cancer
H A Van den BrenkC Sharpington

Abstract

The growth of an allogeneic rapidly growing and metastasizing sarcoma (P-388) in the rat is described. Quantitative and kinetic data are provided concerning the growth of individual metastases produced in three principal regional lymph node drainage groups, and are compared with growth of the primary tumour of origin in muscle; the incidence of pulmonary metastases is also given. The effects on growth of metastases and primaries produced by sublethal whole body irradiation (WBI) before inoculations of 10-10(8) tumour cells are described.Growth of P-388 sarcoma in unirradiated recipients (ED(50) ≃ 5 × 10(3) cells) obeyed the linear growth law proposed by the Mayneord model for tumour growth, but in irradiated recipients (ED(50) < 10 cells) early growth of primaries and metastases approximated more closely to an exponential rate of growth.The ratio M/P of weight of metastases (M) to weight of primary tumour of origin (P) increased at a linear rate with age (t) of tumour, and gave the same slope namely, 0·029 for pelvic node metastases) in unirradiated rats inoculated with a large (10(6)-10(7)) number of cells as in irradiated rats. The slope was decreased to 0·014 for pelvic node metastases in unirradiated rats challenged with fe...Continue Reading

Citations

Jun 15, 1972·Experientia·H A van den Brenk, C Sharpington
Aug 15, 1974·International Journal of Cancer. Journal International Du Cancer·B J WestonA J Davies

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