PMID: 15237705Jul 9, 2004Paper

Growth patterns and final height of survivors of childhood leukemia

Journal of Pediatric Endocrinology & Metabolism : JPEM
Somchit JaruratanasirikulHutcha Sriplung

Abstract

Growth patterns of 85 survivors of childhood leukemia were analyzed retrospectively. All patients remained in first remission with no central nervous system involvement. The mean age at diagnosis was 5.8 +/- 3.6 years. The diagnoses were acute lymphoblastic leukemia (ALL) in 68 patients (80%) and acute non-lymphoblastic leukemia (ANLL) in 17 patients (20%). All except two patients received cranial irradiation: 51 patients with 1,800 cGy and 32 patients with 2,400 cGy. Mean height SDS was -0.7 +/- 1.36 at the time of diagnosis, which decreased to -0.92 +/- 1.31 by the end of treatment, and further decreased to -1.14 +/- 1.38 at 6 years after cessation of treatment. Mean weight SDS was -0.55 +/- 1.13 at the time of diagnosis, increasing slightly to -0.39 +/- 1.02 at the end of treatment, and decreasing to -0.46 +/- 1.65 at 6 years after cessation of treatment. Of these survivors, 51 patients (26 boys and 25 girls) reached a final height that was 1.04 SDS or 5.3 cm less than their target height. There was no difference of height and weight SDS between patients with ALL and ANLL. Girls and boys had different growth patterns. Girls had a slightly increased height SDS and gained more weight after cessation of treatment, resulting in ...Continue Reading

References

Mar 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E A SchriockJ J Ochs
Sep 1, 1995·Acta Paediatrica. Supplement·A L Ogilvy-Stuart, S M Shalet
Aug 26, 1998·Clinical Endocrinology·B M BrennanS M Shalet
Nov 10, 2001·The Journal of Clinical Endocrinology and Metabolism·L AdanR Brauner

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Citations

May 22, 2010·International Journal of Hematology·Samart PakakasamaSomjai Kanjanapongkul
Jul 26, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sarah ElitzurShlomit Shalitin
Feb 9, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Pankaj KumarDeepak Bansal

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