PMID: 6990470Mar 1, 1980Paper

Growth patterns of human acute lymphoblastic leukaemia in diffusion chambers befor treatment and after cessation of therapy

Scandinavian Journal of Haematology
A FontebuoniG Lucarelli

Abstract

Diffusion Chambers (DC) were used to culture human bone marrow of ALL patients at the beginning and after the cessation of therapy. No growth was observed in patients before treatment, while growth patterns similar to the normal were obtained in patients after 3 years of maintenance therapy. We suggested the possibility of intensifying the multiple drug chemotherapy in ALL without permanent damage of the stem cell proliferative compartment.

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