Growth Plate Suppression in an Adolescent Patient With Acute Lymphoblastic Leukemia After Treatment

Clinical Nuclear Medicine
Ekaterina TiktinskyJoseph Kapelushnik

Abstract

Osteotoxic effect is a common adverse effect of chemotherapy for childhood acute lymphoblastic leukemia. The pathophysiology of impaired bone growth is multifactorial and can affect both osteoblast and osteoclast function. Significant contribution in affecting skeletal metabolism belongs to high-dose corticosteroid treatment. We present the case of a 12-year-old adolescent girl who was treated for high-risk pro-B acute lymphoblastic leukemia. The Tc-MDP bone scan, as a sensitive indicator of osteoblastic activity, shows that growth plate inhibition after intensive treatment may be temporary and reversible.

References

Jan 6, 1999·Archives of Disease in Childhood·V V KhadilkarR Stanhope
Sep 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L A MattanoJ B Nachman
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J StraussL B Silverman
Mar 22, 2002·AJR. American Journal of Roentgenology·Kirsten Ecklund, Diego Jaramillo
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karen MandelPaul Pencharz
Jun 26, 2010·Archives of Disease in Childhood·M ElmantaserS F Ahmed
Dec 18, 2010·Endocrine Development·Julian C Lui, Jeffrey Baron
Aug 18, 2012·Clinical Nuclear Medicine·Remy Lim, Jorge A Carrasquillo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.