PMID: 8942852Dec 1, 1996Paper

Growth-regulated alpha expression in the peritoneal environment with endometriosis

Obstetrics and Gynecology
E OralA Arici

Abstract

To investigate the presence and modulation of growth-regulated alpha, a member of the chemokine family with neutrophil chemotactic activity, in the peritoneal fluid of women with or without endometriosis. Peritoneal fluid samples were obtained at laparoscopy from 63 women with endometriosis and 19 fertile women without endometriosis. Endometrial tissue was obtained from uteri after hysterectomy for reasons other than endometrial disease or from endometrial biopsies of reproductive-age women. Cellular RNA was extracted and northern blots were hybridized with an oligonucleotide probe complementary to a specific sequence of growth-regulated alpha messenger RNA. Growth-regulated alpha in peritoneal fluid and culture supernatant was quantified using enzyme-linked immunosorbent assay. Statistical analyses were performed using Kruskal-Wallis and Mann-Whitney tests. The median (range) concentration of growth-regulated alpha in peritoneal fluid samples from 19 normal fertile women was 27 pg/mL (0-108), from 24 women with moderate endometriosis 34 pg/mL (8-150), and from seven with severe endometriosis was 73 pg/mL (10-221) (P = .04, P = .01, respectively). In the moderate and severe endometriosis groups, the levels of growth-regulated a...Continue Reading

References

May 1, 1990·The Journal of Experimental Medicine·B MoserM Baggiolini
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S HaskillR Sager
Dec 1, 1989·American Journal of Obstetrics and Gynecology·J Halme
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A AnisowiczR Sager
Apr 1, 1987·American Journal of Obstetrics and Gynecology·J HalmeS Haskill
Aug 1, 1993·Molecular and Cellular Endocrinology·A AriciM L Casey
Feb 1, 1993·American Journal of Obstetrics and Gynecology·M C LeivaC R Lyttle
Oct 1, 1962·The Journal of Obstetrics and Gynaecology of the British Empire·S W WRIGHT

❮ Previous
Next ❯

Citations

Jun 9, 1999·Fertility and Sterility·J A García-Velasco, A Arici
Mar 30, 2013·Human Reproduction Update·Fernando M ReisRobert N Taylor
Nov 30, 2013·Human Reproduction·G M BorrelliS Mechsner
Jun 19, 2002·American Journal of Reproductive Immunology : AJRI·Umit A KayisliAydin Arici
Jun 26, 2012·Cytokine & Growth Factor Reviews·Magali RancezRémi Cheynier
Nov 25, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Nobuhiro SuzumoriKaoru Suzumori
Feb 26, 2005·Annals of the New York Academy of Sciences·Gülden Halis, Aydin Arici
Jan 10, 2018·The Journal of Obstetrics and Gynaecology Research·Gentaro IzumiYutaka Osuga
Jun 1, 1997·Obstetrics and Gynecology Clinics of North America·E Oral, A Arici

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.