Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization

Molecular Human Reproduction
Alison J CamdenRamakrishna Kommagani


Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial stromal cell (HESC) decidualization. Successful establishment of pregnancy requires HESCs to transform from fibroblastic to epithelioid cells in a process called decidualization. This process depends on the hormone progesterone, but the molecular mechanisms by which it occurs have not been determined. Primary and transformed HESCs in which GREB1 expression was knocked down were decidualized in culture for up to 6 days. Wild-type and progesterone receptor (PR) knockout mice were treated with progesterone, and their uteri were assessed for levels of GREB1 expression. Analysis of previous data included data mining of expression profile data sets and in silico transcription factor-binding analysis. Endometrial biopsies obtained from healthy women of reproductive age during the proliferative phase (Days 8-12) of their menstrual cycle were used for isolating HESCs. Experiments were carried out with early passage (no more than four passages) HESCs isolated from at least three subjects. Transcript levels of ...Continue Reading


Mar 1, 1991·Baillière's Clinical Obstetrics and Gynaecology·T Chard
Jan 1, 1988·Annals of the New York Academy of Sciences·R H Foote, E W Carney
Aug 1, 1972·Biology of Reproduction·C A Finn, L Martin
Sep 15, 1995·Genes & Development·J P LydonB W O'Malley
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
May 19, 1998·Human Reproduction Update·V C Stevens
Jun 11, 1999·The New England Journal of Medicine·A J WilcoxC R Weinberg
Jul 7, 2000·Developmental Biology·D D CarsonK Yoshinaga
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wen-ge MaSudhansu K Dey
Jan 17, 2004·Endocrinology·Graciela KrikunCharles J Lockwood
Jun 30, 2005·Breast Cancer Research and Treatment·James M RaeMarc E Lippman
Feb 18, 2006·Nature Reviews. Genetics·Haibin Wang, Sudhansu K Dey
Feb 24, 2006·The Prostate·James M RaeMarc E Lippman
Aug 4, 2007·Journal of Assisted Reproduction and Genetics·John Rinehart
Oct 26, 2007·Seminars in Reproductive Medicine·Birgit GellersenJan J Brosens
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Amrita DasIndrani C Bagchi
Feb 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anita K DunbierMitch Dowsett
Sep 18, 2010·Molecular Human Reproduction·G TeklenburgJan J Brosens
Apr 27, 2012·Reproductive Sciences·Philip C LoganMurray D Mitchell
May 29, 2012·Molecular Endocrinology·Cory A RubelFrancesco J DeMayo
Jun 12, 2012·Biochimica Et Biophysica Acta·Y E M KootN S Macklon
Jun 27, 2012·Nature Reviews. Endocrinology·David M Lonard, Bert W O'Malley
Jul 13, 2012·Physiological Genomics·Scott A OchsnerNeil J McKenna
Dec 12, 2012·Nature Medicine·Jeeyeon ChaSudhansu K Dey
Feb 14, 2013·Cell Reports·Hisham MohammedJason S Carroll
Sep 10, 2013·The Journal of Clinical Endocrinology and Metabolism·D A GibsonP T K Saunders
Jan 29, 2014·International Journal of Cancer. Journal International Du Cancer·Laura A LavioletteBarbara C Vanderhyden
Feb 8, 2014·Scientific Reports·Jan J BrosensNick S Macklon
Jul 16, 2014·The International Journal of Developmental Biology·Margeaux Wetendorf, Francesco J DeMayo
Sep 5, 2014·Biology of Reproduction·Nick S Macklon, Jan J Brosens
Feb 11, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Kirsty A WaltersDouglas A Gibson
Apr 14, 2016·Journal of Molecular Endocrinology·Douglas A GibsonPhilippa T K Saunders

❮ Previous
Next ❯


Dec 27, 2019·Endocrinology·Arin K OestreichRamakrishna Kommagani
May 17, 2019·The American Journal of Surgical Pathology·Cheng-Han LeeJen-Chieh Lee
Jul 17, 2018·Biology of Reproduction·Koji Yoshinaga
Aug 30, 2018·International Journal of Molecular Sciences·Meng ChengRamakrishna Kommagani
Dec 20, 2019·Acta Biochimica Et Biophysica Sinica·Yifei SangMeirong Du
Jun 19, 2020·Healthcare·Antonio Sanchez-FernandezMaría Pedrera-Canal
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Sangappa B ChadchanRamakrishna Kommagani
Mar 27, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Britt DuijndamBob van de Water

❮ Previous
Next ❯

Related Concepts

Related Feeds

Advanced Imaging of Cellular Signaling

Cell signaling is a vital mechanism for communication within cells and outside with the environment. Several different signaling pathways have been found and advanced imaging techniques are being developed to visualize the molecules involved in these signaling pathways. Find the latest research in advanced imaging of cellular signaling here.