Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization

Molecular Human Reproduction
Alison J CamdenRamakrishna Kommagani

Abstract

Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial stromal cell (HESC) decidualization. Successful establishment of pregnancy requires HESCs to transform from fibroblastic to epithelioid cells in a process called decidualization. This process depends on the hormone progesterone, but the molecular mechanisms by which it occurs have not been determined. Primary and transformed HESCs in which GREB1 expression was knocked down were decidualized in culture for up to 6 days. Wild-type and progesterone receptor (PR) knockout mice were treated with progesterone, and their uteri were assessed for levels of GREB1 expression. Analysis of previous data included data mining of expression profile data sets and in silico transcription factor-binding analysis. Endometrial biopsies obtained from healthy women of reproductive age during the proliferative phase (Days 8-12) of their menstrual cycle were used for isolating HESCs. Experiments were carried out with early passage (no more than four passages) HESCs isolated from at least three subjects. Transcript levels of ...Continue Reading

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Citations

Dec 27, 2019·Endocrinology·Arin K OestreichRamakrishna Kommagani
May 17, 2019·The American Journal of Surgical Pathology·Cheng-Han LeeJen-Chieh Lee
Jul 17, 2018·Biology of Reproduction·Koji Yoshinaga
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Jun 19, 2020·Healthcare·Antonio Sanchez-FernandezMaría Pedrera-Canal
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Sangappa B ChadchanRamakrishna Kommagani
Mar 27, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Britt DuijndamBob van de Water

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