Growth responses of cartilage to static and dynamic compression

Clinical Orthopaedics and Related Research
K W LiR L Sah

Abstract

During skeletal development, growth, and maturation, gradual changes in the material properties and physical dimensions of cartilage occur under the influence of mechanical loading. The objective of the current study was to compare glycosaminoglyean biosynthesis and cell proliferation in fetal, calf, and adult bovine cartilage explants, isolated from defined depths from the articular surface, in response to controlled compressive loads. Mechanical testing confirmed that for all cartilage samples subjected to load, there was a marked time-averaged (static) compression, whereas the addition of dynamic load at a frequency of 0.01 Hz induced dynamic strain with amplitude and phase shift characteristics typical of stimuli that previously were found to be associated with stimulation of glycosaminoglycan synthesis. In metabolic studies, the application of static loading (84 kPa) for 24 hours inhibited glycosaminoglycan and deoxyribonucleic acid synthesis in all cultured cartilage samples. The superposition of dynamic loading (200 kPa, 0.01 Hz) induced a 20% stimulation of glycosaminoglycan biosynthesis in calf cartilage from the middle-deep zones over statically-loaded samples and an additional approximate 50% suppression of deoxyribo...Continue Reading

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Citations

Jul 19, 2006·Tissue Engineering·Travis J KleinRobert L Sah
May 27, 2006·Arthritis and Rheumatism·Gayle E NugentRobert L Sah
Aug 3, 2007·Computer Methods in Biomechanics and Biomedical Engineering·Bruce GardinerLihai Zhang
Sep 2, 2008·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·J A Kaupp, S D Waldman
Aug 16, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Amanda K WilliamsonRobert L Sah
Aug 10, 2006·Annals of Biomedical Engineering·Adam C Aufderheide, Kyriacos A Athanasiou
Oct 19, 2010·Tissue Engineering. Part C, Methods·Trevor J LujanMichael Bottlang
Mar 1, 2018·Journal of Tissue Engineering and Regenerative Medicine·Nopporn SawatjuiTravis Klein
Mar 19, 2005·The Journal of Bone and Joint Surgery. British Volume·S E FarmerW Bromwich
May 10, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kyle D JadinRobert L Sah
Sep 19, 2006·Clinical Orthopaedics and Related Research·Ian HendersonBarry Oakes
Sep 26, 2006·Tissue Engineering·Kelvin W LiGary S Beaupre
May 4, 2004·Best Practice & Research. Clinical Rheumatology·Najia Shakoor, Kirsten Moisio
Dec 21, 2005·Medical Hypotheses·R A BrandJ K Udupa

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