Growth restriction before or after birth reduces nephron number and increases blood pressure in male rats

Kidney International
Mary E WlodekKaren M Moritz

Abstract

Impaired growth in utero predicts a low nephron number and high blood pressure later in life as does slowed or accelerated growth after a normal birth weight. We measured the effects of early postnatal growth restriction, with or without prenatal growth restriction, on blood pressure and nephron number in male rat offspring. Bilateral uterine artery and vein ligation were performed to induce uteroplacental insufficiency (Restricted) on day 18 of pregnancy. Postnatal growth restriction was induced in a subset of sham operated control animals by reducing the number of pups at birth to that of the Restricted group (Reduced Litter). Compared to Controls, Restricted pups were born smaller while Reduced Litter pups weighed less by postnatal day 3 and both groups remained lighter throughout lactation. By 10 weeks of age all animals were of similar weight but the Reduced Litter rats had elevated blood pressure. At 22 weeks, Restricted but not Reduced Litter offspring were smaller and the blood pressure was increased in both groups. Restricted and Reduced Litter groups had fewer glomeruli and greater left ventricular mass than Controls. These results suggest that restriction of both perinatal and early postnatal growth increase blood pr...Continue Reading

References

Feb 12, 1999·BMJ : British Medical Journal·J G ErikssonD J Barker
Apr 20, 2001·BMJ : British Medical Journal·J G ErikssonD J Barker
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Marie-Claude BattistaMichèle Brochu
Feb 22, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Karen M MoritzE Marelyn Wintour
May 20, 2003·Kidney International·Michael HughsonJohn F Bertram
Apr 22, 2004·American Journal of Physiology. Renal Physiology·V Matti VehaskariJennifer Manning
Jul 27, 2004·Kidney & Blood Pressure Research·Monika A ZimanyiM Jane Black
Sep 17, 2004·Pediatric Research·Lori L Woods, Douglas A Weeks
Sep 18, 2004·Science·Peter D Gluckman, Mark A Hanson
Sep 18, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Cristina CebriánDoris A Herzlinger
Oct 14, 2004·Annals of Medicine·Tom J ForsénDavid J P Barker
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Elena VelkoskaMargaret J Morris
Jan 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mary E WlodekJane M Moseley
Apr 23, 2005·Cell and Tissue Research·Karen M MoritzE Marelyn Wintour
Jun 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lori L WoodsRuth Rasch
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Mai Thanh TuClaire-Dominique Walker
Aug 10, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Nagesh S Anavekar, Scott D Solomon
Dec 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Barbara T Alexander
Jun 16, 2006·American Journal of Physiology. Renal Physiology·Michiel F SchreuderHenriette A Delemarre-van de Waal
Jul 20, 2006·The Journal of Clinical Hypertension·Sverre E KjeldsenPeter M Okin
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Gabrielle L GallagherStephen N Hunyor
Apr 20, 2007·Journal of the American Society of Nephrology : JASN·Mary E WlodekKaren M Moritz

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Citations

Aug 5, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jörg DötschJulie Ingelfinger
Apr 25, 2012·Cell and Tissue Research·Linda A GalloMary E Wlodek
Feb 8, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jörg DötschKerstin Amann
Feb 4, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lee O'SullivanKaren M Moritz
Dec 1, 2010·Journal of Developmental Origins of Health and Disease·G D WadleyG K McConell
Feb 1, 2012·Journal of Developmental Origins of Health and Disease·B LauritzM E Wlodek
Feb 2, 2011·Nature Reviews. Nephrology·Eberhard RitzKerstin Benz
Mar 4, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Miguel Angel Alejandre AlcázarJörg Dötsch
Aug 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·N KoleganovaK Amann
Dec 13, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maarten B Rookmaaker, Jaap A Joles
Dec 17, 2008·Biology of Reproduction·Yong ChengKeith E Latham
Apr 16, 2013·Clinical and Experimental Pharmacology & Physiology·Linda A GalloMary E Wlodek
Mar 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M Jane BlackMary E Wlodek
Mar 5, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A AugustyniakNoreen F Rossi
Oct 2, 2009·American Journal of Physiology. Renal Physiology·Michel Baum
May 7, 2011·Journal of Pregnancy·Erich CosmiVincenzo Zanardo
Nov 16, 2013·Pediatric Research·Hyung Eun YimJoo Won Lee
Apr 2, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Emily S DoreyKaren M Moritz
Jun 27, 2014·Journal of Developmental Origins of Health and Disease·S van der LindeD H Hryciw
Oct 4, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Daniela FanniVassilios Fanos
Jul 26, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paul J RoderickJohn Wright
Oct 18, 2015·Clinical and Experimental Pharmacology & Physiology·V F I RichterD H Hryciw
Jun 21, 2011·Current Problems in Pediatric and Adolescent Health Care·Kara Calkins, Sherin U Devaskar
Aug 4, 2015·Journal of Developmental Origins of Health and Disease·P NuñezC Perillan
Mar 26, 2016·Frontiers in Physiology·Amanda N Sferruzzi-Perri, Emily J Camm
Sep 10, 2014·Clinical and Experimental Pharmacology & Physiology·Jordanna S MasterMary J Black
Mar 24, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michel Baum
Nov 26, 2013·Acta Physiologica·N B OjedaB T Alexander

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