PMID: 9437263Jan 23, 1998Paper

Growth retardation in premenarchial female rhesus monkeys during chronic administration of GnRH agonist (leuprolide acetate)

Journal of Medical Primatology
M S GolubM E Gershwin

Abstract

Leuprolide acetate in depot form (0.75 mg/kg body weight/month, i.m.) was administered to four female rhesus monkeys from 18-30 months of age, a period that includes the premenarchial growth spurt. They were compared to eight age matched controls. As anticipated, sexual maturation was blocked in the Leuprolide group and menarche did not occur. Growth was also severely retarded; no weight gain occurred during the study in the Leuprolide group as compared to a 25% weight gain (P = .044) in the control group. The Leuprolide group also lost muscle mass. Food intake normalized for body weight was not affected. Linear growth averaged 35% less in the Leuprolide group. Serum IGF-1 concentrations increased from 486 +/- 84 to 965 +/- 47 ng/mL (P = .0025) in the Leuprolide group and from 838 +/- 139 to 3,006 +/- 545 ng/mL (P = .0016) in the control group. These data suggest that premenarchial pituitary/gonadal suppression results in a distinctive pattern of growth retardation in monkeys.

References

Mar 1, 1992·Biological Psychiatry·E H Friedman
May 1, 1988·Endocrine Reviews·M D Wheeler, D M Styne
Oct 11, 1988·The American Journal of Physiology·P A BoeppleW F Crowley
Jun 1, 1988·Hormones and Behavior·S M SchwartzD C Collins
Jun 1, 1974·General and Comparative Endocrinology·B C HummelJ C Paice
Mar 1, 1966·Endocrinology·R L AbramsW H Daughaday
Feb 5, 1968·Annals of the New York Academy of Sciences·E Knobil, V Meyer
Feb 1, 1984·The American Journal of Clinical Nutrition·M S GolubA G Hendrickx
Feb 1, 1995·Cellular and Molecular Neurobiology·E Terasawa
Aug 1, 1994·The American Journal of Clinical Nutrition·M S GolubB Lonnerdal
Sep 1, 1996·The American Journal of Clinical Nutrition·M S GolubA G Hendrickx
Mar 1, 1996·American Journal of Physical Anthropology·T L Blackwelder, M S Golub
Jan 1, 1990·American Journal of Human Biology : the Official Journal of the Human Biology Council·J M TannerC G Rudman

❮ Previous
Next ❯

Citations

Jun 1, 2011·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Gina M FerrieTammie Bettinger
Feb 15, 2008·Pediatrics·Germaine M Buck LouisSusan Y Euling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.