PMID: 8972532Nov 1, 1996Paper

Growth suppression in children receiving acetazolamide with antiepileptic drugs

Pediatric Neurology
Y FutagiJ Abe

Abstract

To clarify the effect of the clinical dosage of acetazolamide on growth in children with epilepsy or febrile convulsion, the standard scores of height and weight in 17 subjects receiving acetazolamide as an adjunct to unchanged monotherapy of antiepileptic drug were compared longitudinally through four phases: before antiepileptic drug administration, with monotherapy of antiepileptic drug, with acetazolamide in addition to monotherapy, and after acetazolamide discontinuation. The standard scores of both height and weight in the subjects were significantly reduced during the phase of acetazolamide administration. During this period, serum concentrations of potassium and total CO2 decreased while that of chloride increased, suggesting the existence of metabolic acidosis in the subjects. For both height and weight, there was no correlation between the degree of standard score reduction during acetazolamide administration and age at the time of acetazolamide initiation, duration of acetazolamide administration, dosages of acetazolamide, and variety of antiepileptic drugs concomitantly administered with acetazolamide. We speculate that metabolic acidosis induced by acetazolamide suppressed the growth of the subjects and that there ...Continue Reading

References

Jun 1, 1978·Clinical Endocrinology·R NaeijeL Vanhaelst
Oct 1, 1978·Kidney International·E McSherry
Jan 1, 1986·American Journal of Nephrology·F Santos, J C Chan
Nov 17, 1973·Lancet·R B Tattersall, D A Pyke
Mar 1, 1983·The Journal of Pediatrics·J C Chan
Aug 1, 1956·Neurology·J G MILLICHAP

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Citations

Jun 26, 2001·Epilepsia·L L LimJ Lee
May 15, 2010·Epilepsy Research·Elahna PaulElizabeth A Thiele
Feb 5, 2010·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Sapna SharanAlex V Levin
Feb 14, 2009·Journal of Pediatric Ophthalmology and Strabismus·Greet CoppensIngele Casteels
Oct 31, 2006·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Kourosh Sabri, Alex V Levin
Dec 20, 2007·American Journal of Therapeutics·Mark E Schneiderhan, Robert Marvin
Aug 31, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Anne Tasaki

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