Grueneberg ganglion cells mediate alarm pheromone detection in mice

Science
Julien BrechbühlMarie-Christine Broillet

Abstract

Alarm pheromones (APs) are widely used throughout the plant and animal kingdoms. Species such as fish, insects, and mammals signal danger to conspecifics by releasing volatile alarm molecules. Thus far, neither the chemicals, their bodily source, nor the sensory system involved in their detection have been isolated or identified in mammals. We found that APs are recognized by the Grueneberg ganglion (GG), a recently discovered olfactory subsystem. We showed with electron microscopy that GG neurons bear primary cilia, with cell bodies ensheathed by glial cells. APs evoked calcium responses in GG neurons in vitro and induced freezing behavior in vivo, which completely disappeared when the GG degenerated after axotomy. We conclude that mice detect APs through the activation of olfactory GG neurons.

References

Jul 1, 1991·Physiology & Behavior·C Zalaquett, D Thiessen
Jun 15, 1989·The Journal of Comparative Neurology·K ShinodaY Osawa
May 30, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·H Grüneberg
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·M K StoweJ H Tumlinson
Mar 1, 1993·The Journal of General Virology·M TemonenH Lankinen
Jun 24, 2000·Nature·T Leinders-ZufallF Zufall
Mar 10, 2001·Physiology & Behavior·T KikusuiY Mori
Aug 28, 2001·Journal of Chemical Ecology·R S Mirza, D P Chivers
Aug 9, 2003·Nature·Masato OnoMasami Sasaki
Apr 23, 2004·Proceedings. Biological Sciences·Michel C MilinkovitchJeffrey R Powell
Oct 27, 2004·Proceedings. Biological Sciences·Edward B Mondor, Bernard D Roitberg
Feb 16, 2005·Annual Review of Physiology·Helle A Praetorius, Kenneth R Spring
Jun 18, 2005·Chemical Senses·Yasushi KiyokawaYuji Mori
Sep 29, 2005·Forensic Science International : Synergy·Roman HauserLucja Wodniak-Ochocińska
Nov 8, 2005·Neuroreport·David S Koos, Scott E Fraser
Nov 26, 2005·The European Journal of Neuroscience·Stefan H FussPeter Mombaerts
Dec 24, 2005·The Journal of Comparative Neurology·Melonie Joanne Storan, Brian Key
Jun 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael H BealeYuhua Zhang
Jun 30, 2006·Journal of Neurochemistry·Jörg FleischerHeinz Breer
Jul 6, 2006·The European Journal of Neuroscience·Daniele RoppoloIvan Rodriguez
Aug 5, 2006·Science·Veena Singla, Jeremy F Reiter
Nov 17, 2006·Nature·Peter A Brennan, Frank Zufall
Apr 6, 2007·Physiology & Behavior·Ana G Gutiérrez-GarcíaJ Samuel Cruz-Sánchez
Jun 9, 2007·Chemical Senses·Joerg FleischerHeinz Breer

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Citations

Feb 9, 2012·Cell and Tissue Research·Kristin DaunerFrank Möhrlen
Apr 23, 2013·Cell and Tissue Research·Laura M HuckinsGabriela Sánchez-Andrade
Mar 9, 2013·Molecules and Cells·Anders Enjin, Greg Seong-Bae Suh
Nov 27, 2009·Molecular and Cellular Biochemistry·Frank Zufall, Steven D Munger
Dec 24, 2009·Nature Reviews. Neuroscience·Shai Shaham
Dec 15, 2010·Chemical Senses·Katharina MamasuewJoerg Fleischer
Nov 1, 2011·Chemical Senses·Yuichiro OkaSigrun I Korsching
Jul 4, 2013·Chemical Senses·Yasushi KiyokawaYuji Mori
Sep 30, 2010·The Journal of Veterinary Medical Science·Kazumi TaniguchiKazuyuki Taniguchi
Jun 25, 2009·PloS One·Alexander Prehn-KristensenBettina M Pause
Jul 19, 2011·PloS One·Piray AtsakChristian Keysers
Dec 14, 2011·Journal of Visualized Experiments : JoVE·Julien BrechbühlMarie-Christine Broillet
Aug 31, 2013·Annual Review of Physiology·Stephen D Liberles
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Julien BrechbühlMarie-Christine Broillet
Oct 9, 2013·Cellular and Molecular Neurobiology·Sabrina StebeJoerg Fleischer
Aug 5, 2009·Cellular and Molecular Life Sciences : CMLS·Aya Kato, Kazushige Touhara
Feb 19, 2010·Cellular and Molecular Life Sciences : CMLS·Katharina MamasuewJoerg Fleischer
Mar 27, 2012·Chemosensory Perception·Bettina M Pause
Apr 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ricardo VillaresCarlos Martínez-A
Jul 20, 2010·Micron : the International Research and Review Journal for Microscopy·Policarp Hortolà
Mar 27, 2010·Current Opinion in Neurobiology·Lisa Stowers, Darren W Logan
Aug 12, 2009·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Bettina M PauseRoman Ferstl
Jul 1, 2015·Hormones and Behavior·Kelsy S J ErvinElena Choleris
Oct 22, 2008·Current Opinion in Neurobiology·Andreas Keller, Leslie B Vosshall
Feb 11, 2014·Scientific Reports·Gaurav AhujaSigrun I Korsching
Apr 23, 2009·Journal of Neurochemistry·Marc Spehr, Steven D Munger
Jul 1, 2009·The Journal of Comparative Neurology·Cambrian Y LiuDavid S Koos
Aug 19, 2009·Annals of the New York Academy of Sciences·Stuart J Firestein
Jun 26, 2010·Human Brain Mapping·Johannes FrasnelliMarilyn Jones-Gotman
Aug 2, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Lluis Fortes-MarcoFernando Martinez-Garcia
Aug 2, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Antonio AbellánLoreta Medina
Jun 1, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ti-Fei Yuan, Burton M Slotnick
Apr 9, 2013·Progress in Retinal and Eye Research·Jillian N PearringVadim Y Arshavsky
Aug 19, 2015·Frontiers in Neuroscience·Julien BrechbühlMarie-Christine Broillet

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