Grüneisen-relaxation photoacoustic microscopy at 1.7  µm and its application in lipid imaging

Optics Letters
Jiawei ShiKenneth K Y Wong

Abstract

We report the first, to the best of our knowledge, demonstration of Grüneisen relaxation photoacoustic microscopy (GR-PAM) of lipid-rich tissue imaging at the 1.7 µm band, implemented with a high-energy thulium-doped fiber laser and a fiber-based delay line. GR-PAM enhances the image contrast by intensifying the region of strong absorbers and suppressing out-of-focus signals. Using GR-PAM to image swine-adipose tissue at 1725 nm, an 8.26-fold contrast enhancement is achieved in comparison to conventional PAM. GR-PAM at the 1.7 µm band is expected to be a useful tool for label-free high-resolution imaging of lipid-rich tissue, such as atherosclerotic plaque and nerves.

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Citations

Nov 19, 2020·Journal of Biophotonics·Mingsheng LiLidai Wang
May 1, 2021·Visual Computing for Industry, Biomedicine and Art·Long Jin, Yizhi Liang
Jan 4, 2022·Journal of Biophotonics·Myeongsu SeongSung-Liang Chen

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