Gsh-1: a novel murine homeobox gene expressed in the central nervous system

Developmental Dynamics : an Official Publication of the American Association of Anatomists
M T ValeriusS S Potter

Abstract

We report the characterization of Gsh-1, a novel murine homeobox gene. Northern blot analysis revealed a transcript of approximately 2 kb in size present at embryonic days 10.5, 11.5, and 12.5 of development. The cDNA sequence encoded a proline rich motif, a polyalanine tract, and a homeodomain with strong homology to those encoded by the clustered Hox genes. The Gsh-1 expression pattern was determined for days E8.5 to E13.5 by whole mount and serial section in situ hybridizations. Gsh-1 transcription was restricted to the central nervous system. Expression is present in the neural tube and hindbrain as two continuous, bilaterally symmetrical stripes within neural epithelial tissue. In the mesencephalon, expression is seen as a band across the most anterior portion. There is also diencephalon expression in the anlagen of the thalamus and the hypothalamus as well as in the optic stalk, optic recess, and the ganglionic eminence. Moreover, through the use of fusion proteins containing the Gsh-1 homeodomain, we have determined the consensus DNA binding site of the Gsh-1 homeoprotein to be GCT/CA/CATTAG/A.

References

Dec 1, 1979·Annals of Neurology·L R Squire, R Y Moore
Jan 24, 1992·Cell·W McGinnis, R Krumlauf
Mar 1, 1992·Differentiation; Research in Biological Diversity·P DolléD Duboule
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S LuF H Ruddle
Dec 11, 1992·The Journal of Experimental Zoology·S KaurS S Potter
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G SinghS S Potter
Nov 1, 1991·Early Human Development·J Mojsilović, N Zecević
Feb 1, 1989·Genes & Development·W F OdenwaldR A Lazzarini
Jan 1, 1987·Schizophrenia Bulletin·A F Oke, R N Adams
Jul 1, 1988·Genes & Development·P W Holland, B L Hogan
Apr 1, 1995·Mechanisms of Development·H M Hsieh-LiS S Potter
Nov 1, 1993·Genes & Development·D WilsonC Desplan
Dec 1, 1993·Genes & Development·K M Small, S S Potter

❮ Previous
Next ❯

Citations

Dec 17, 1997·Developmental Biology·J C SzucsikS S Potter
May 13, 2005·Molecular and Cellular Endocrinology·A Rosanas-UrgellJ Garcia-Fernàndez
Feb 13, 2001·Mechanisms of Development·C Hudson, P Lemaire
Dec 1, 1996·Current Opinion in Cell Biology·M Treier, M G Rosenfeld
Jan 23, 1999·Current Opinion in Neurobiology·J S Eisen
Feb 19, 2000·Current Opinion in Neurobiology·R A Cornell, T V Ohlen
Feb 19, 2000·Current Opinion in Neurobiology·L W JurataS L Pfaff
Mar 11, 1999·Current Opinion in Neurobiology·A B Chitnis
Jun 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·John F MulleyPeter W H Holland
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Guoyan ZhaoJames B Skeath
Jan 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zhenglei PeiKenneth Campbell
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·F FalcianiS Brown
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·F R GoodmanP J Scambler
Mar 14, 2007·Molecular and Cellular Biology·Hui-Yi Chu, Akihira Ohtoshi
May 9, 2012·Anatomy Research International·A E EvansA E Rosser
Sep 20, 2008·BMC Developmental Biology·Masanori Takahashi, Noriko Osumi
Jun 28, 2013·BMC Biology·Rossella AnnunziataMaria Ina Arnone
Jul 25, 2009·BMC Biology·Jerome H L HuiDavid E K Ferrier
May 11, 2005·PLoS Biology·Antigoni EkonomouVasso Episkopou
Mar 5, 2016·BMC Evolutionary Biology·Myles G GarstangDavid E K Ferrier
May 4, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Emily F WinterbottomHarry V Isaacs
Nov 10, 2004·Gene Expression Patterns : GEP·Sarah E Cheesman, Judith S Eisen
Sep 17, 2014·Molecular Psychiatry·S A BergeronH A Burgess
Sep 29, 2007·Mechanisms of Development·T Von OhlenD M Mellerick
May 20, 1999·Mechanisms of Development·C KioussiM G Rosenfeld
Aug 2, 2011·Genomics, Proteomics & Bioinformatics·Tetsuro Ikuta
Sep 9, 2016·Neurogenesis·Ryan N DelgadoDaniel A Lim
Jun 29, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Rolf Urbach, Gerhard M Technau
Jun 6, 2018·Cell and Tissue Research·Gonzalo Alvarez-Bolado
Apr 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tony OosterveenJohan Ericson
Aug 15, 2019·Brain : a Journal of Neurology·Roberta De MoriEnza Maria Valente

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.