GSH-Activated Light-Up Near-Infrared Fluorescent Probe with High Affinity to αv β3 Integrin for Precise Early Tumor Identification

ACS Applied Materials & Interfaces
Zhenwei YuanHaiyan Chen

Abstract

The development of tumor-associated, stimuli-driven, turn-on near-infrared (NIR) fluorophores requires urgent attention because of their potential in selective and precise tumor diagnosis. Herein, we describe a NIR fluorescent probe (CyA-cRGD) comprised of a fluorescence reporting unit (a cyanine dye) linked with a GSH-responsive unit (nitroazo aryl ether group) and a tumor-targeting unit (cRGD). The NIR fluorescence of CyA-cRGD with sensitive and selective response to GSH can act as a direct off-on signal reporter for GSH monitoring. Notably, CyA-cRGD possesses improved biocompatibility compared with CyA, which is highly desirable for in vivo fluorescence tracking of cancer. Confocal fluorescence imaging confirmed the tumor-targeting capability and GSH detection ability of CyA-cRGD in tumor cells, normal cells, and coincubated tumor /normal cells and in the three-dimensional multicellular tumor spheroid. Furthermore, it was validated that CyA-cRGD could detect tumor precisely in GSH and integrin αvβ 3 high-expressed tumor-bearing mouse models. Importantly, it was confirmed that CyA-cRGD possessed high efficiency for early-stage tumor imaging in mouse models with tumor cells implanted within 72 h. This method provided significa...Continue Reading

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Citations

Jan 3, 2019·Biomaterials Science·Yue SunXiaobing Wang
Sep 19, 2019·Chemistry, an Asian Journal·Jiamin WangJianhong Wang
Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qianru MaYufen Zhao

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