PMID: 1174555Sep 8, 1975Paper

GSH biosynthesis in glutathione deficient erythrocytes from Finnish landrace and Tasmanian merino sheep

Biochimica Et Biophysica Acta
J D Young, I A Nimmo

Abstract

1. The maximum activities of the enzymes for the biosynthesis of GSH (gamma-glutamyl-cysteine synthetase and GSH synthetase) have been assayed in high GSH and low GSH erythrocytes from Tasmanian Merino and Finnish Landrace sheep. 2. For the Merinos, the activities (mumol product/g haemoglobin per min +/- S.E.M. (n)) in the high and low GSH erythrocytes respectively were: gamma-glutamyl-cysteine synthetase: 0.776 +/- 0.065 (11) and 0.375 +/- 0.063 (13); and GSH synthetase: 0.069 +/- 0.003 (11) and 0.066 +/- 0.002 (13). 3. For the Finnish Landrace sheep the activities in the high and low GSH erythrocytes respectively were: gamma-glutamyl-cysteine synthetase: 0.595 +/- 0.063 (12) and 0.555 +/- 0.033 (10) and gamma-glutamyl-cysteine synthetase: 0.073 +/- 0.002 (12) and 0.070 +/- 0.002 (10). 4. gamma-Glutamyl-cysteine synthetase was markedly inhibited by physiological GSH concentrations. No evidence was found for the presence of an inhibitor of GSH biosynthesis (other than GSH) in low GSH erythrocytes from Finnish Landrace sheep. 5. Although for the Merinos the low GSH trait can be explained in terms of a diminished activity of gamma-glutamyl-cysteine synthetase, no such explanation is tenable for the Finnish Landrace sheep.

References

Sep 1, 1973·Comparative Biochemistry and Physiology. A, Comparative Physiology·E M TuckerL Kilgour
Feb 1, 1969·The Biochemical Journal·R C Jackson
Mar 16, 1972·The New England Journal of Medicine·P N KonradD E Paglia
Oct 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·J Roberts, N S Agar
Oct 20, 1967·Science·J E Smith, B I Osburn

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Citations

Oct 1, 1983·Biochemical Genetics·E M TuckerJ D Young
Aug 1, 1982·Biochemical Genetics·J D YoungL Kilgour
Jan 11, 2013·Oxidative Medicine and Cellular Longevity·Dusica Z DjordjevicVladimir Lj Jakovljevic
May 1, 1977·The Proceedings of the Nutrition Society·E M Tucker
Jan 1, 1976·Animal Blood Groups and Biochemical Genetics·E M Tucker
Aug 15, 1985·Biochemical Pharmacology·A M Mann, F J Darby
May 2, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y IshidaS Miwa
Nov 18, 1980·Biochimica Et Biophysica Acta·J D Young

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