GSK-3beta and alpha-catenin binding regions of beta-catenin exert opposing effects on the terminal ventral optic axonal projection

Developmental Dynamics : an Official Publication of the American Association of Anatomists
A WileyTamira M Elul

Abstract

We overexpressed two deletion mutants of the N-terminal domain of beta-catenin in ventral optic axons in living Xenopus tadpoles. One deletion mutant contained both the alpha-catenin and the GSK-3beta binding sites of the N-terminal domain of beta-catenin (NTERM), and the second deletion mutant contained only the GSK-3beta binding site (beta-cat107). Expression of NTERM in ventral optic axons dispersed and induced anterior and lateral shifts in their targeting locations in the dorsal tectum. In contrast, beta-cat107 compressed and shifted the synaptic targeting locations of ventral optic axons medially and posteriorly. In addition, NTERM-expressing ventral optic axons formed arbors that were wider than controls whereas beta-cat107 axonal arbors were narrower compared with controls. These data suggest that the interactions of beta-catenin with alpha-catenin and GSK-3beta exert opposing effects on the terminal projections of ventral optic axons.

References

Oct 1, 1993·Journal of Neurobiology·C E Holt, W A Harris
Dec 12, 2001·Biochemistry. Biokhimii︠a︡·D B IvanovV A Tkachuk
May 20, 2003·Nature Neuroscience·Roger C LeeS Lawrence Zipursky
Mar 6, 2004·Science·W James Nelson, Roel Nusse
Apr 28, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jane M GoodingMitsuhiko Ikura

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