GSTM1 and CYP1A1 polymorphisms, tobacco, air pollution, and lung cancer: a study in rural Thailand

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Paola PisaniD Timothy Bishop

Abstract

The Lampang Province is situated in the northern region of Thailand. Incidence rates of lung cancer are high for Asian standards, particularly in women. This study was conducted to quantify the risk of lung cancer associated with exposures prevalent in the area and to investigate possible interactions with genetic susceptibility. The presence of several large open-cast coal mines from 1955 close to electricity-generating plants was a particular focus of concern. Two-hundred and eleven cases of primary lung cancers diagnosed in 1993 to 1995 and residents in the province were recruited at the Lampang Provincial Hospital (main referral center for treatment of the disease). Two sets of controls, frequency-matched to the cases by sex and age, were recruited (a) from the resident population (202 interviewed) and (b) from patients admitted to the hospital for diseases predominantly unrelated to tobacco smoking (211 interviewed). Sociodemographic information, complete residential history, and characteristics of the household (place of cooking, cooking fuel, and heating fuels), occupational history, and history of tobacco smoking were obtained by interview. Cases and controls ( approximately 50% of the population-based series) provided ...Continue Reading

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Citations

Jul 9, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chun-hua XuLi-Ke Yu
Sep 6, 2012·Molecular Human Reproduction·M D MustafaKiran Guleria
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Oct 22, 2011·Journal of Experimental & Clinical Cancer Research : CR·Ping ZhanLi-Ke Yu
May 9, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kyoung-Mu LeeEmanuela Taioli
May 7, 2021·Genetic Testing and Molecular Biomarkers·Yongbo HouGuoxiang Wang

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