GSTM1 polymorphism and oral leukoplakia

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Eliza Carla Barroso DuarteRicardo Santiago Gomez

Abstract

Molecular epidemiological studies have now provided evidence that an individual susceptibility to cancer is mediated by genetic and environmental factors. Genetic polymorphisms have been described for enzymes involved in the metabolism of tobacco carcinogens and cancer risk is determined by the degree of expression and/or activity of enzymes involved in carcinogen activation or deactivation. The objective of this study was to investigate the GSTM1 null polymorphism and the risk for oral leukoplakia in individuals with tobacco-smoking habit in a Brazilian population. A total of 52 tobacco-smoking patients with oral leukoplakia and 52 tobacco-smoking controls were recruited in a Brazilian population. The GSTM1 genotypes were studied by polymerase chain reaction-based methods. The frequency of the GSTM1 null genotype in the group with oral leukoplakia (57.7%) was statistically different from the controls (34.6%; OR: 2.57, 95% CI: 1.16-5.69, P < 0.05). The stratification of the samples according to the level of dysplasia showed increased prevalence of GSTM1 null genotype on lesions with moderate/severe histological dysplasia (68.2%) compared with the control group (31.9%). This difference was statistically significant (OR: 4.59, 95...Continue Reading

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Citations

May 7, 2016·Genetic Testing and Molecular Biomarkers·Pengfei HeQing Liu
Oct 11, 2016·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Renu TanwarB V Subhash
Apr 27, 2010·Indian Journal of Dermatology·Uwe Wollina
Jan 1, 2016·Stomatologii︠a︡·A A Bezrukov, V A Syomkin

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