GSTM3 and GSTP1: novel players driving tumor progression in cervical cancer

Oncotarget
Alberto Checa-RojasSergio Encarnación-Guevara

Abstract

The molecular processes and proteomic markers leading to tumor progression (TP) in cervical cancer (CC) are either unknown or only partially understood. TP affects metabolic and regulatory mechanisms that can be identified as proteomic changes. To identify which proteins are differentially expressed and to understand the mechanisms of cancer progression, we analyzed the dynamics of the tumor proteome in CC cell lines. This analysis revealed two proteins that are up-regulated during TP, GSTM3 and GSTP1. These proteins are involved in cell maintenance, cell survival and the cellular stress response via the NF-κB and MAP kinase pathways during TP. Furthermore, GSTM3 and GSTP1 knockdown showed that evasion of apoptosis was affected, and tumor proliferation was significantly reduced. Our data indicate the critical role of GST proteins in the regulation and progression of cervical cancer cells. Hence, we suggest GSTM3 and GSTP1 as novel biomarkers and potential therapeutic targets for treating cervical cancer. CC is particularly hazardous in the advanced stages, and there are few therapeutic strategies specifically targeting these stages. We performed analyses on CC tumor proteome dynamics and identified GSTM3 and GSTP1 as novel pote...Continue Reading

References

Jan 1, 1989·Cancer Chemotherapy and Pharmacology·M M Tomayko, C P Reynolds
Oct 1, 1989·Analytical Biochemistry·W KuengU Eppenberger
Oct 17, 1998·Molecular Cell·H NishitohH Ichijo
Mar 4, 1999·The EMBO Journal·V AdlerZ Ronai
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·A CabelguenneI De Waziers
Feb 12, 2002·The Journal of Biological Chemistry·Alexzander AseaStuart K Calderwood
Mar 29, 2002·Journal of Clinical Pathology·F X BoschK V Shah
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Apr 3, 2003·Nature Reviews. Cancer·Julia D WulfkuhleEmanuel F Petricoin
Jun 17, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jingxiang HuangBoon-Huat Bay
Jun 26, 2003·Nucleic Acids Research·Torsten SchwedeManuel C Peitsch
Jul 2, 2003·Proteomics·Sergio EncarnaciónJaime Mora
Jul 5, 2003·Lancet·Steven E Waggoner
Oct 25, 2003·Oncogene·Danyelle M Townsend, Kenneth D Tew
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·John D HayesIan R Jowsey
Oct 27, 2005·Molecular Cancer·Alfonso Dueñas-GonzálezEduardo Cervera
Jul 29, 2008·Cancer Treatment Reviews·D PectasidesE Pectasides
Jul 22, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anirban P MitraRichard J Cote
Aug 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·John C PriceSina Ghaemmaghami
Aug 25, 2010·Nature Reviews. Cancer·Samir Hanash, Ayumu Taguchi
Mar 1, 2011·Drug Metabolism Reviews·Kenneth D Tew, Danyelle M Townsend
Feb 4, 2012·Genes & Development·Matthew S Hayden, Sankar Ghosh
Apr 17, 2012·Gynecologic Oncology·Flora ZagouriRupert Bartsch
May 11, 2012·Nucleic Acids Research·Daniel Tabas-MadridAlberto Pascual-Montano
Jun 20, 2012·Annals of Internal Medicine·Virginia A Moyer, UNKNOWN U.S. Preventive Services Task Force
Sep 26, 2013·Nature Reviews. Cancer·Caitriona HolohanPatrick G Johnston
Dec 4, 2013·Journal of the Association for Research in Otolaryngology : JARO·Jiwon ChangSung Won Chae
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Nov 4, 2015·Nucleic Acids Research·Juan Antonio VizcaínoHenning Hermjakob

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Citations

Apr 4, 2019·Molecular Cancer·Ladan MashouriSuresh K Alahari
Mar 7, 2019·Scientific Reports·Evangelia TsergaDavid M Baguley
Jul 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aleksandra BocianJaroslav Legáth
Oct 30, 2020·Cancer Management and Research·Shunda WangYupei Zhao
May 6, 2021·Antioxidants·Rahul Raj Singh, Katie M Reindl
Jul 28, 2020·Current Pharmaceutical Design·Georgios PremetisNikolaos E Labrou
Oct 26, 2021·Reviews in Medical Virology·Alfredo Cruz-GregorioJosé Pedraza-Chaverri

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Datasets Mentioned

BETA
PXD005466

Methods Mentioned

BETA
xenografts
Co-immunoprecipitation
coimmunoprecipitation
pull-down
MDA
antisense oligonucleotides
Gene knock-down
xenograft
co-IP
biopsy

Software Mentioned

SnapGene Viewer
GeneCodis
DeepView )
MAMMOTH
ZEN
XLSTAT
Deep View )
Cytoscape
bisogenet
MASCOT Distiller

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