GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell

Biochemical Pharmacology
Anjaneyulu Kowluru, Noel G Morgan

Abstract

It is widely believed that guanine nucleotide-binding regulatory proteins (G-proteins) play central roles as "molecular switches" in a variety of cellular processes ranging from signal transduction to protein and vesicle trafficking. To achieve these regulatory functions, G-proteins form complexes with a wide range of effector molecules whose activities are altered upon interaction with the G-protein. These effector molecules can be either soluble or membrane bound, and it is likely that some are localized to secretory granules where they direct the movement, docking, and fusion of granules during exocytosis. The effector molecules regulated by G-proteins are diverse and include phospholipases, protein kinases, protein phosphatases, ion channels, adenylate cyclases, cytoskeletal elements, as well as secretory vesicle and plasma membrane-associated fusion-proteins. The majority of studies performed in the pancreatic beta-cell have focused on the role of G-proteins in the regulation of insulin secretion, whereas very little attention has been focused on their potential involvement in other cellular processes. Such studies have identified and implicated both heterotrimeric (comprising alpha, beta, and gamma subunits) and monomeric...Continue Reading

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Citations

Nov 6, 2009·Endocrine Reviews·Anjaneyulu Kowluru
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Rajesh AminAnjaneyulu Kowluru
Nov 1, 2002·The Journal of Biological Chemistry·Yazhou LiDaniel J Drucker
Sep 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Anjaneyulu Kowluru

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