GTP hydrolysis mechanism of Ras-like GTPases

Journal of Molecular Biology
Guangpu Li, Xuejun C Zhang

Abstract

The Ras-like GTPases regulate diverse cellular functions via the chemical cycle of binding and hydrolyzing GTP molecules. They alternate between GTP- and GDP-bound conformations. The GTP-bound conformation is biologically active and promotes a cellular function, such as signal transduction, cytoskeleton organization, protein synthesis/translocation, or a membrane budding/fusion event. GTP hydrolysis turns off the GTPase switch by converting it to the inactive GDP-bound conformation. The fundamental GTP hydrolysis mechanism by these GTPases has generated considerable interest over the last two decades but remained to be firmly established. This review provides an update on the catalytic mechanism with discussions on recent developments from kinetic, structural, and model studies in the context of the various GTP hydrolysis models proposed over the years.

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G G PrivéS H Kim
Jan 1, 1991·Annual Review of Cell Biology·G Bollag, F McCormick
Aug 10, 1990·Science·J LyonsH R Bourne
Mar 30, 1990·Science·A KazlauskasJ A Cooper
Jun 15, 1990·Cell·A Hall
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S C BurkA G Redfield
Jan 1, 1987·Annual Review of Biochemistry·A G Gilman
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J B GibbsE M Scolnick
Jan 1, 1987·Annual Review of Biochemistry·M Barbacid
Jul 1, 1994·Nature Structural Biology·T SchweinsA Warshel
Mar 10, 1995·The Journal of Biological Chemistry·S HoffenbergB F Dickey
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·C KleussA G Gilman
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L Van AelstM Wigler
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·K A MaegleyD Herschlag

❮ Previous
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Citations

Jan 16, 2013·Quarterly Reviews of Biophysics·Shina C L KamerlinArieh Warshel
Oct 26, 2012·Journal of Chemical Information and Modeling·Maxime LouetNicolas Floquet
Jan 11, 2007·Journal of the American Chemical Society·Marco De VivoMichael L Klein
Jan 16, 2010·Nature Reviews. Microbiology·Lautaro Diacovich, Jean-Pierre Gorvel
Apr 7, 2005·European Journal of Human Genetics : EJHG·Marjan M van DuistMario De Marchi
Nov 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·TuAnh Ngoc HuynhValley Stewart
Nov 18, 2009·Biochemistry. Biokhimii︠a︡·A V NemukhinX Du
Oct 21, 2010·Cancer Research·Tonia C JorgensonNorman R Drinkwater
Sep 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Carsten KöttingKlaus Gerwert
Sep 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Cristina MaracciMarina V Rodnina
Feb 6, 2010·Current Opinion in Microbiology·Ruth E Silversmith
May 18, 2007·Journal of Molecular Graphics & Modelling·Christoph WelschStefan Zeuzem
Sep 8, 2011·Molecular Microbiology·TuAnh Ngoc Huynh, Valley Stewart
Sep 27, 2005·Trends in Pharmacological Sciences·Jayesh C PatelJorge E Galán
Apr 5, 2016·The Journal of Physical Chemistry. B·Maria G KhrenovaAlexander V Nemukhin
Nov 9, 2011·Nucleus·Andrew W FolkmannSusan R Wente
Apr 20, 2005·Structure·Sebastiano Pasqualato, Jacqueline Cherfils
Jul 24, 2012·Structure·Mohammad T Mazhab-JafariMitsuhiko Ikura
Jan 3, 2006·Molecular Cell·Joseph D MougousCarolyn R Bertozzi
Jan 1, 2014·Molecular Simulation·Priyanka Prakash, Alemayehu A Gorfe
Dec 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Daniel MannCarsten Kötting
Sep 12, 2018·Physical Chemistry Chemical Physics : PCCP·Bella L GrigorenkoAlexander V Nemukhin
Oct 31, 2015·The Journal of Biological Chemistry·Ryan KnihtilaCarla Mattos
Jan 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Arvind SinghGayatri Ramakrishna
Nov 6, 2007·Journal of Cellular and Molecular Medicine·Marian E DurkinNicholas C Popescu
Jul 4, 2008·Nature·Martin LaurbergHarry F Noller
May 2, 2019·Organic & Biomolecular Chemistry·Bella L GrigorenkoAlexander V Nemukhin
Mar 15, 2016·Biopolymers·Cristina Maracci, Marina V Rodnina
Mar 1, 2017·Biological Chemistry·Klaus GerwertCarsten Kötting
Mar 7, 2014·Acta Crystallographica. Section D, Biological Crystallography·Oleg NikonovMaria Garber
Oct 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan ZhouJingzhi Pu
Jan 9, 2015·Molecular Cancer Research : MCR·Jillian A Parker, Carla Mattos
Apr 10, 2021·International Journal of Biological Macromolecules·Guanghui Ren, Guorong Li
Jun 20, 2013·Journal of Cell Science·Joshua S Chappie, Fred Dyda
Jun 18, 2021·Small GTPases·Tushar Dubey, Subashchandrabose Chinnathambi
Dec 14, 2017·Biochemistry·Jia LuKenneth D Westover
Nov 15, 2012·Biochemistry·Casey O'Connor, Evgenii L Kovrigin
Nov 23, 2006·Journal of the American Chemical Society·Marco KlähnArieh Warshel

❮ Previous
Next ❯

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