PMID: 16526276Mar 11, 2006Paper

Guaiane sesquiterpenoids from Torilis japonica and their cytotoxic effects on human cancer cell lines

Archives of Pharmacal Research
Hye Won ParkDae Keun Kim

Abstract

A new compound 2 and two known guaiane-type sesquiterpenoids were isolated from the methylene chloride-soluble fraction of the methanolic extract of the fruits of Torilis japonica (Umbelliferae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as torilin (1), 11-acetoxy-8-angeloyloxy-1beta-hydroxy-4-guaien-3-one (1beta-hydroxytorilin, 2), and 11-acetoxy-8-angeloyloxy-1alpha-hydroxy-4-guaien-3-one (1alpha-hydroxytorilin, 3) by spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Jan 17, 2002·Archives of Pharmacal Research·J H Ryu, Y S Jeong
Apr 9, 2002·Phytochemistry·Junichi KitajimaMitsuo Watanabe
Jun 13, 2003·Planta medica·Won Seok ParkChang Hoon Lee

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Citations

Nov 24, 2006·Archives of Pharmacal Research·Yong Geun KwakJae Soon Eun
Apr 30, 2013·International Immunopharmacology·Mehari EndaleManhee Rhee
Oct 17, 2014·Magnetic Resonance in Chemistry : MRC·Hai-Bo LiXin-Sheng Yao
Nov 23, 2007·Natural Product Reports·Braulio M Fraga
Jan 5, 2010·Chemical & Pharmaceutical Bulletin·Hong-Wei FuJing-Kui Tian
Dec 24, 2018·Marine Drugs·Mei-Jun ChuGuo-Qiang Li

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