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Guanethidine and related agents. 3. Antagonism by drugs which inhibit the norepinephrine pump in man

The Journal of Clinical Investigation

Aug 1, 1970

J R MitchellJ A Oates

Abstract

Antagonism of the antihypertensive action of guanethidine by the tricyclic antidepressants, desipramine and protriptyline, has been demonstrated in controlled studies. These antidepressants also prevent the effect of the related ring-substituted guanidinium adrenergic neuron blockers, b...read more

Mentioned in this Paper

Z-Max
ratio-Desipramine
Amines
Debrisoquin
Diastolic Blood Pressure
Neurons
Uptake
Sembrina
Protriptyline
Guanethidine Sulfate (2: 1), 14C-Labeled
Paper Details
References
  • References6
  • Citations25
1
  • References6
  • Citations25
123

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Guanethidine and related agents. 3. Antagonism by drugs which inhibit the norepinephrine pump in man

The Journal of Clinical Investigation

Aug 1, 1970

J R MitchellJ A Oates

PMID: 5431666

DOI: 10.1172/jci106377

Abstract

Antagonism of the antihypertensive action of guanethidine by the tricyclic antidepressants, desipramine and protriptyline, has been demonstrated in controlled studies. These antidepressants also prevent the effect of the related ring-substituted guanidinium adrenergic neuron blockers, b...read more

Mentioned in this Paper

Z-Max
ratio-Desipramine
Amines
Debrisoquin
Diastolic Blood Pressure
Neurons
Uptake
Sembrina
Protriptyline
Guanethidine Sulfate (2: 1), 14C-Labeled

Similar Papers Found In These Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Lancet

METHYLDOPA AND AMITRIPTYLINE

LancetAugust 28, 1965
A G WHITE
European Journal of Clinical Pharmacology

The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man

European Journal of Clinical PharmacologySeptember 1, 1979
J L ReidC R Dean
Paper Details
References
  • References6
  • Citations25
1
  • References6
  • Citations25
123
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