Guanidiniocarbonyl-Pyrroles (GCP) - 20 Years of the Schmuck Binding Motif

Michael GieseJens Voskuhl


In this Minireview, an overview about the past 20 years of the guanidiniocarbonyl-pyrrole (GCP) binding motif, which was designed, investigated and applied by Prof. Dr. Carsten Schmuck, is presented. Here we highlight the first steps from design and discovery, initial binding studies, applications in material science to advanced biomedical use in protein modulation and delivery of genetic material.


Nov 13, 2003·Chembiochem : a European Journal of Chemical Biology·C Schmuck, Martin Heil
Jul 22, 2004·Journal of the American Chemical Society·C Schmuck, Lars Geiger
Mar 10, 2005·Journal of the American Chemical Society·C Schmuck, Michael Schwegmann
Jul 29, 2005·Organic Letters·C Schmuck, Michael Schwegmann
Sep 14, 2006·Chemistry : a European Journal·Carsten SchmuckWolfgang Wienand
Feb 23, 2007·Organic & Biomolecular Chemistry·C Schmuck, Maija Heller
Jun 15, 2007·Chemistry : a European Journal·Carsten SchmuckThomas Schrader
Aug 4, 2007·The Journal of Organic Chemistry·Carsten Schmuck, Volker Bickert
Apr 24, 2008·Chemistry : a European Journal·Davide MoianiCarsten Schmuck
Dec 16, 2011·Chemistry : a European Journal·Tassilo FenskeC Schmuck
May 17, 2013·Journal of the American Chemical Society·M Tassilo FenskeCarsten Schmuck
Oct 15, 2013·Angewandte Chemie·Yosuke HisamatsuCarsten Schmuck
Jul 30, 2014·Chemical Communications : Chem Comm·M Fleischer, C Schmuck
Apr 13, 2019·Organic & Biomolecular Chemistry·Debabrata MaityCarsten Schmuck
Jun 7, 2019·Chembiochem : a European Journal of Chemical Biology·Lina BartschCarsten Schmuck


Oct 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dandan SuSébastien Ulrich
Jan 9, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Vikas KumarSebastian Schlücker
Feb 11, 2021·Beilstein Journal of Organic Chemistry·Alexander Zika, Franziska Gröhn
Feb 2, 2021·Beilstein Journal of Organic Chemistry·Jan-Erik OstwaldtJochen Niemeyer

Related Concepts

Protein Domain
Guanidiniocarbonyl pyrrole carboxylate-phenylalanyl-phenylalanine

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