Guanidino compound metabolism in rats subjected to 20% to 90% nephrectomy

Kidney International
O LevillainP P De Deyn

Abstract

In mammalian kidney, the proximal convoluted tubule (PCT) is the main site of arginine (Arg) production. Arginine can be used in the biosynthesis of guanidino compounds (GC). Since uremic rats have a lower functional mass of PCT, GC synthesis might be modified, especially that of guanidinoacetic acid (GAA) which occurs in PCT. In order to study GC metabolism at different steps of uremia, rats were subjected to either 42% or 80% nephrectomy (NX); the experiment lasted for three weeks. Results show that: (1) in plasma, the pattern of GC levels in 42% NX rats was similar to that of controls except for a clear increase of beta-guanidinopropionic acid (beta-GPA), whereas in 80% NX rats, all GC levels sharply increased except that of creatine which decreased. (2) Urinary excretion of GC in control and 42% NX rats is quite similar except for GAA which strongly decreased, and for homoarginine (HArg) and argininic acid (ArgA) which increased. In rats with 80% NX, the principal modification in GC excretion was a four- to five-fold reduction in GAA output. (3) After induction of renal failure, Arg, creatine and guanidinosuccinic acid reabsorption remained unchanged, and that of HArg decreased. For guanidine and methylguanidine the negativ...Continue Reading

References

Jan 1, 1977·Pflügers Archiv : European journal of physiology·G O PerezE R Schiff
Jun 1, 1992·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·M TakedaH Endou
May 1, 1992·Metabolism: Clinical and Experimental·B MarescauP P De Deyn
Jan 1, 1986·Nephron·S NagaseS Tojo
Apr 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D M McGuireJ F van Pilsum
Jul 1, 1974·Kidney International·J M KaufmanJ P Hayslett
Jan 1, 1973·The American Journal of Physiology·W R FeatherstonR A Freedland
May 1, 1973·Archives of Internal Medicine·S GiovannettiG Barsotti
Apr 15, 1973·Experientia·G C Menichini, S Giovannetti
Jul 1, 1968·The American Journal of Medicine·B D CohenJ E Bonas
May 1, 1969·The American Journal of Physiology·M Bergeron, F Morel
Nov 2, 1993·European Journal of Pharmacology·K HasanR G Tilton
Jul 1, 1992·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·Y KuroyanagiN Shioya

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Citations

Sep 15, 2012·Bulletin of Experimental Biology and Medicine·R A Sukhovershin, M A Gilinsky
Feb 17, 2001·European Journal of Biochemistry·C CabellaS Colombatto
Jan 9, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andreas TomaschitzWinfried März
Jul 1, 2011·Journal of Biomedicine & Biotechnology·Luisa GuerriniGiorgio R Merlo
Jun 23, 2011·Clinical and Experimental Nephrology·Takafumi ToyoharaTakaaki Abe
May 2, 2015·Amino Acids·Stefan PilzAndreas Tomaschitz
May 27, 2008·Metabolism: Clinical and Experimental·Olivier LevillainPeter Paul De Deyn
Feb 27, 2018·Journal of the American Heart Association·Samyuktha Muralidharan PillaiFrançois Verrey
Jul 14, 2000·Physiological Reviews·M Wyss, R Kaddurah-Daouk
Aug 14, 1999·Journal of the American Society of Nephrology : JASN·R Vanholder, R De Smet
Sep 1, 1997·Metabolism: Clinical and Experimental·B MarescauP P De Deyn

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