Guanxinshutong capsule ameliorates cardiac function and architecture following myocardial injury by modulating ventricular remodeling in rats.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Jiaqi ZhuJiehong Yang

Abstract

Guanxinshutong capsule (GXST), which consists of five traditional Chinese medicines, has been used for a long time in China for the treatment of cardiovascular diseases, such as coronary artery disease and myocardial infarction. However, the effects on GXST on myocardial injury (MI) have not been studied in detail. In these experiments, we found that GXST administration decreased MI-associated ventricular remodeling (VR) with a reduction in interventricular septal thickness in diastole (IVSd), left ventricular posterior wall diameter in systole (LVPWs), and left ventricular posterior wall diameter in diastole (LVPWd) to ameliorate cardiac function and architecture, as measured by echocardiography. Furthermore, histological analysis showed that GXST could ameliorate pathological alterations in the myocardium. And Sirius red staining, wheat germ agglutinin staining and inflammation-related immunohistochemistry results showed that GXST ameliorated the fibrosis areas, cardiac hypertrophy and inflammation (IL-6 and TNF-α). In addition, GXST upregulated intercellular junction proteins (N-cad and Cx-43) and downregulated the angiogenesis-related proteins (PDGF and VEGFA), myocardial fibrosis-related proteins (TGF-β1), and matrix metal...Continue Reading

References

Jul 26, 1990·The New England Journal of Medicine·B LevineM Packer
Jan 7, 2003·Biotechnology and Bioengineering·Sindhu M GopalanAndrew D McCulloch
Jan 29, 2005·International Journal of Cardiology·Angelo A IzzoEdzard Ernst
Jul 23, 2005·Current Heart Failure Reports·Anne M Deschamps, Francis G Spinale
Jan 19, 2008·Journal of Molecular and Cellular Cardiology·Jifen LiGlenn L Radice
Oct 3, 2009·Journal of Cell Communication and Signaling·Mark W M SchellingsStephane Heymans
Jan 23, 2010·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Yan ZhangKathryn A Yamada
Feb 2, 2010·Journal of the American College of Cardiology·Oliver AdamUlrich Laufs
Dec 22, 2010·Circulation·Izhak Kehat, Jeffery D Molkentin
Jun 16, 2012·The Journal of Thoracic and Cardiovascular Surgery·Lawrence S LeeFrederick Y Chen
Jun 29, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Amin BoroujerdiRichard Milner
Aug 24, 2012·Journal of Geriatric Cardiology : JGC·Zhuo LiangYa-Ling Han
Apr 14, 2016·European Heart Journal·Henri M H SpronkUlrich Schotten
Nov 20, 2016·Journal of cardiology·Vincenzo GrimaldiClaudio Napoli
Feb 6, 2017·European Journal of Heart Failure·Mariann GyöngyösiFaiez Zannad
Jun 24, 2017·Comprehensive Physiology·My-Nhan NguyenXiao-Jun Du
Jan 10, 2018·Advances in Pharmacology·Xi Wang, Raouf A Khalil
Jun 5, 2018·Heart Failure Reviews·Monika BartekovaNaranjan S Dhalla
Sep 28, 2018·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Dan YangYu-Cheng Chen
Nov 18, 2018·International Journal of Molecular Sciences·Akira SaitoTakahide Nagase

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Citations

Feb 24, 2021·BMC Complementary Medicine and Therapies·Xiaoxiao ZhangNing Gu

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