Guanxintai Exerts Protective Effects on Ischemic Cardiomyocytes by Mitigating Oxidative Stress

Evidence-based Complementary and Alternative Medicine : ECAM
Jing YangLu Fu

Abstract

Oxidative stress participates in numerous myocardial pathophysiological processes and is considered a therapeutic target for myocardial ischemia and heart failure. Guanxintai (GXT), a traditional Chinese medicine, is commonly used to treat cardiovascular disease on account of its numerous beneficial physiological activities, such as dilating coronary arteries, inhibiting platelet aggregation, and reducing the serum lipid content. However, the antioxidative properties of GXT and potential underlying mechanisms remain to be established. In the present study, we investigated the protective effects of GXT on ischemic cardiomyocytes and the associated antioxidative mechanisms, both in vivo and in vitro. Notably, GXT treatment reduced the degree of cardiomyocyte injury, myocardial apoptosis, and fibrosis and partially improved cardiac function after myocardial infarction. Furthermore, GXT suppressed the level of ROS as well as expression of NADPH oxidase (NOX) and phospho-p38 mitogen-activated protein kinase (MAPK) proteins. Our results collectively suggest that the protective effects of GXT on ischemic cardiomyocytes are exerted through its antioxidative activity of NOX inhibition.

References

Mar 13, 2001·Biochemical and Biophysical Research Communications·T FukuiY Abe
Mar 1, 2003·Journal of Clinical Pathology·P A J KrijnenH W M Niessen
Aug 19, 2008·Lancet·Harvey D White, Derek P Chew
Dec 3, 2008·Cardiovascular Research·Masatsugu Hori, Kazuhiko Nishida
May 21, 2011·Basic Research in Cardiology·Alexander SirkerAjay M Shah
Oct 29, 2015·BioMed Research International·Tingyang ZhouLi Zuo

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Citations

Mar 29, 2019·Oxidative Medicine and Cellular Longevity·Xinyu YangHongcai Shang

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Methods Mentioned

BETA
flow cytometry
Protein Assay
electrophoresis
X-ray
PCR

Software Mentioned

Image J
Image
Pro Plus
SPSS

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