Guava flavonoid glycosides prevent influenza A virus infection via rescue of P53 activity

Journal of Medical Virology
Hany KhalilSamir El-Masry

Abstract

Influenza is a highly infectious disease caused by three types of viruses, including influenza A virus (IAV), influenza B virus, and, rarely, influenza C virus. IAV is a major, global public health threat, causing approximately 500 000 deaths per year worldwide. The new strains of IAV have emerged due to a mutation called antigenic shift, which results in a new subtype of the virus that shows resistance to common antiviral drugs. Here, guava and lemon extracts, including green leaves and flowers, were investigated for their activity against IAV replication in human A549 cells. Concomitantly, the cytotoxicity of a potent extract on host-cell multiplication was assessed. Our results reveal that guava extracts inhibit IAV replication, indicated by viral nucleoprotein expression profile and traditional plaque assay. Interestingly, treatment with guava extract inactivates Akt protein kinase and stimulates the pro-apoptotic protein P53, at early stages of infection. Furthermore, purified guava flavonoid glycosides (GFGs) show competitive inhibition of IAV-virus replication via early regulation of IL-1β and IL-8 in association with P53 gene expression. The docking analysis of GFGs and the protein structure of upstream targets for the ...Continue Reading

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Citations

Feb 18, 2020·Frontiers in Cell and Developmental Biology·Ahmed I Abd El MaksoudHany Khalil
Nov 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Asad UllahMariusz Jaremko

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