Guest-host interactions of nanoconfined anti-cancer drug in metal-organic framework exposed by terahertz dynamics

Chemical Communications : Chem Comm
Barbara E SouzaJin-Chong Tan

Abstract

A facile mechanochemical method was employed to accomplish one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU as guest) in a metal-organic framework (HKUST-1 as host). Vibrational spectroscopy via inelastic neutron scattering was applied to probe guest-host interactions arising from nanoscale confinement. We compare 5-FU@HKUST-1 derived from in situ and ex situ encapsulation.

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Citations

Jan 12, 2021·Biomaterials Science·Monireh FalsafiMona Alibolandi
May 6, 2021·Polymers·Kacper DrużbickiFelix Fernandez-Alonso
Jun 11, 2019·Journal of the American Chemical Society·Brian PattengaleCharles A Schmuttenmaer
Jun 12, 2019·Journal of the American Chemical Society·Christian SchneiderGregor Kieslich

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Datasets Mentioned

BETA
RB1810348

Methods Mentioned

BETA
X-ray
Atomic Force Microscopy
AFM
inelastic neutron scattering

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