Guidance for the procurement of COVID-19 convalescent plasma: differences between high- and low-middle-income countries.

Vox Sanguinis
Evan M BlochCynthia So-Osman

Abstract

COVID-19 convalescent plasma (CCP) has been used, predominantly in high-income countries (HICs) to treat COVID-19; available data suggest the safety and efficacy of use. We sought to develop guidance for procurement and use of CCP, particularly in low- and middle-income countries (LMICs) for which data are lacking. A multidisciplinary, geographically representative group of individuals with expertise spanning transfusion medicine, infectious diseases and haematology was tasked with the development of a guidance document for CCP, drawing on expert opinion, survey of group members and review of available evidence. Three subgroups (i.e. donor, product and patient) were established based on self-identified expertise and interest. Here, the donor and product-related challenges are summarized and contrasted between HICs and LMICs with a view to guide related practices. The challenges to advance CCP therapy are different between HICs and LMICs. Early challenges in HICs related to recruitment and qualification of sufficient donors to meet the growing demand. Antibody testing also posed a specific obstacle given lack of standardization, variable performance of the assays in use and uncertain interpretation of results. In LMICs, an extan...Continue Reading

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Citations

Nov 10, 2020·Vox Sanguinis·Sheila F O'BrienUNKNOWN Surveillance, Risk Assessment, Policy Sub-group of the ISBT Transfusion Transmitted Infectious Diseases Working Party
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