Guided mass spectrum labelling in atom probe tomography

Ultramicroscopy
D HaleyD Raabe

Abstract

Atom probe tomography (APT) is a valuable near-atomic scale imaging technique, which yields mass spectrographic data. Experimental correctness can often pivot on the identification of peaks within a dataset, this is a manual process where subjectivity and errors can arise. The limitations of manual procedures complicate APT experiments for the operator and furthermore are a barrier to technique standardisation. In this work we explore the capabilities of computer-guided ranging to aid identification and analysis of mass spectra. We propose a fully robust algorithm for enumeration of the possible identities of detected peak positions, which assists labelling. Furthermore, a simple ranking scheme is developed to allow for evaluation of the likelihood of each possible identity being the likely assignment from the enumerated set. We demonstrate a simple, yet complete work-chain that allows for the conversion of mass-spectra to fully identified APT spectra, with the goal of minimising identification errors, and the inter-operator variance within APT experiments. This work chain is compared to current procedures via experimental trials with different APT operators, to determine the relative effectiveness and precision of the two appr...Continue Reading

References

Sep 29, 2007·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Christian OberdorferGuido Schmitz
Jul 14, 2010·Journal of Mass Spectrometry : JMS·Hisayuki HoraiTakaaki Nishioka
Jan 18, 2011·Ultramicroscopy·M ThuvanderH-O Andrén
Jul 17, 2012·Bioinformatics·Sebastian Gibb, Korbinian Strimmer
Jan 9, 2013·Ultramicroscopy·Mattias ThuvanderHans-Olof Andrén

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Citations

Mar 17, 2017·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Andrew J LondonMichael P Moody
Feb 15, 2019·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Andrew J London
Mar 1, 2019·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Francois VurpillotFrederic Danoix
Jan 31, 2017·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Daniel HaleyMichael P Moody
Aug 20, 2020·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Daniel HaleyMichael P Moody
Dec 8, 2020·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Jens KeutgenOana Cojocaru-Mirédin
May 6, 2019·Micron : the International Research and Review Journal for Microscopy·F VogelG B Thompson
Jun 12, 2020·Ultramicroscopy·Frederick MeisenkothenEric B Steel
Jul 29, 2021·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Ty J Prosa, Edward Oltman
Jul 28, 2021·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Markus KühbachAnna V Ceguerra

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