Guided periodontal tissue regeneration in Class II furcation defects following treatment with a synthetic bioabsorbable barrier
Abstract
The purpose of this study was to evaluate guided periodontal tissue regeneration (GPTR) wound healing in Class II furcation defects following surgical treatment with a synthetic bioabsorbable barrier manufactured from a copolymer of glycolide and lactide. Periodonal lesions were induced in four adult male rhesus monkeys around the mandibular first, second, and third molar teeth using orthodontic elastics. After obtaining approximately 30% bone loss, the elastics were replaced by a stainless steel wire which had a projection extending into the furcation. Once similar contralateral Class II furcation defects had been created, the wires were removed, and an oral hygiene program was initiated and maintained until completion of the study. Three weeks after commencing oral hygiene, flap surgery was performed in the mandibular molar region and the root surfaces were thoroughly scaled and root planed to the apical portion of the defects. A bioabsorbable barrier was then placed to cover the furcation defects on one side of the jaw (i.e., test sites). No barriers were placed on the contralateral molars (i.e., control sites). Five months after surgery, the animals were sacrificed and the teeth with their supporting periodontium were proce...Continue Reading
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Poly(Lactic-co-Glycolic Acid): Applications and Future Prospects for Periodontal Tissue Regeneration
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