Guided tissue regeneration combined with a deproteinized bovine bone mineral (Bio-Oss) in the treatment of intrabony periodontal defects: 6-year results from a randomized-controlled clinical trial

Journal of Clinical Periodontology
Andreas Stavropoulos, T Karring

Abstract

To present the 6-year results of a randomized-controlled clinical trial evaluating guided tissue regeneration (GTR) combined with or without deproteinized bovine bone mineral (DBBM) in intrabony defects. In each of 45 patients, one defect was treated with GTR combined with DBBM hydrated in saline (DBBM-) or gentamicin sulphate (DBBM+) or with GTR alone. Clinical parameters were recorded pre-surgery, at 1 and 6 years postsurgery. Thirty-six patients/33 teeth were available for the 6-year control. Statistically significant clinical improvements were observed for all treatments. Clinical attachment level (CAL) gain averaged 2.5 mm (DBBM-), 4.1 mm (DBBM+), and 3.0 mm (GTR) at 1 year postsurgery, and remained stable over 5 additional years (2.3, 4.1, and 2.7 mm, respectively). Treatment did not appear to influence residual probing depths (PDs) or CAL gains at 6 years postsurgery, or the extent of PD and CAL change from 1 to 6 years, and did not associate with sites losing CAL during follow-up. No association of grafting with sites showing CAL gain >or=4 mm at the 1- or 6-year control was observed. The improvements in periodontal conditions obtained after GTR treatment with or without the adjunct use of DBBM can be preserved on a lon...Continue Reading

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Citations

Oct 1, 2013·BioMed Research International·Quan LiuHaobo Pan
Oct 9, 2014·Clinical Oral Investigations·Eduardo Aleixo FigueiraBruno César de Vasconcelos Gurgel
Sep 30, 2014·Clinical Oral Implants Research·Seref EzirganliMehmet S Aydin
Nov 19, 2011·Clinical Oral Implants Research·Şeref EzirganlıHakan Hamdi Çelik
Dec 30, 2014·Clinical Oral Implants Research·Stefano MilaniClaudia Dellavia
Nov 13, 2012·Archives of Oral Biology·Hakan OzdemirEmre Baris
Mar 18, 2017·Journal of Clinical Periodontology·Frank BröselerSøren Jepsen
Feb 17, 2019·Letters in Applied Microbiology·E SweeneyS M Nelson
Apr 2, 2019·International Journal of Implant Dentistry·Leonidas BatasAndreas Stavropoulos
Sep 13, 2012·Journal of Biomedical Materials Research. Part a·L-C GerhardtA R Boccaccini
Aug 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lihong LeiZhongru Gou
Jul 3, 2021·Materials·Leonardo ManciniEnrico Marchetti

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