Guideline compliance for bridging anticoagulation use in vitamin-K antagonist patients; practice variation and factors associated with non-compliance

Thrombosis Journal
Marco J MoeskerCordula Wagner

Abstract

Bridging anticoagulation is used in vitamin-K antagonist (VKA) patients undergoing invasive procedures and involves complex risk assessment in order to prevent thromboembolic and bleeding outcomes. Our aim was to assess guideline compliance and identify factors associated with bridging and especially, non-compliant bridging. A retrospective review of 256 patient records in 13 Dutch hospitals was performed. Demographic, clinical, surgical and care delivery characteristics were collected. Compliance to the American College of Chest Physicians ninth edition guideline (AT9) was assessed. Multilevel regression models were built to explain bridging use and predict non-compliance. Bridging use varied from 15.0 to 83.3% (mean = 41.8%) of patients per hospital, whereas guideline compliance varied from 20.0 to 88.2% (mean = 68.5%) per hospital. Both established thromboembolic risk factors and characteristics outside thromboembolic risk assessment were associated with bridging use. Predictors for overuse were gastrointestinal surgery (OR 14.85, 95% CI 2.69-81.99), vascular surgery (OR 13.01, 95% CI 1.83-92.30), non-elective surgery (OR 8.67, 95% CI 1.67-45.14), lowest 25th percentile socioeconomic status (OR 0.33, 95% CI 0.11-1.02) and us...Continue Reading

References

Jul 11, 2007·Archives of Internal Medicine·Diane K WysowskiLynette Swartz
Sep 1, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Andrew D KrahnDavid H Birnie
Jan 28, 2010·The American Journal of Medicine·Amir K JafferRichard H White
Sep 4, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Lilian H F HoonhoutMaurits W van Tulder
Feb 10, 2011·Circulation. Cardiovascular Quality and Outcomes·Lesli E SkolarusDevin L Brown
Mar 26, 2011·Chest·Alex C SpyropoulosUNKNOWN IMPROVE Investigators
Jun 21, 2011·The American Journal of Medicine·David M ShahianHui Zheng
Apr 20, 2012·Health Economics·Guido Erreygers
Sep 18, 2012·Pacing and Clinical Electrophysiology : PACE·Mark J PerrinDavid H Birnie
May 11, 2013·The New England Journal of Medicine·David H BirnieUNKNOWN BRUISE CONTROL Investigators
Apr 22, 2014·Thrombosis Research·Annick SteibJacques Fusciardi
Jul 6, 2014·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·L Van De SteegC Wagner
Jun 23, 2015·The New England Journal of Medicine·James D DouketisUNKNOWN BRIDGE Investigators
Sep 19, 2015·Journal of the American College of Cardiology·Stephen J Rechenmacher, James C Fang
May 20, 2016·Pharmacoepidemiology and Drug Safety·Nikki L DamenMaaike Langelaan
Jul 9, 2016·Journal of the American College of Cardiology·Greg C FlakerJohn U Doherty
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Sep 23, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Thomas DelateNathan P Clark
May 2, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A KuijerS G Elias
Jun 13, 2017·Pharmacology Research & Perspectives·Jakob Nørgaard HenriksenBirgitte Klindt Poulsen
Sep 10, 2017·European Heart Journal·Helmut BaumgartnerUNKNOWN ESC Scientific Document Group

❮ Previous
Next ❯

Citations

Dec 17, 2020·Neurological Research and Practice·H TumaniT Zimmermann

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.