Guideline on medical research in older persons

Tijdschrift voor gerontologie en geriatrie
Marjolein A van der Marck, Marcel G M Olde Rikkert

Abstract

This paper describes the development of a guideline on medical research with older subjects. Although our society is aging, evidence on health care for older persons is lacking on many topics, because these subjects are underrepresented in most drug and non-drug trials, while these services are used many older persons, and result in many adverse reactions and unplanned hospitalisation. Part of the reasons for this underrepresentation is the multimorbidity, often leading to exclusion, but also the lack of appropriate research methods plays a major role. Therefore, this paper describes the methods and results of the development of a multidisciplinary, evidence based guideline on how to conduct medical research in older persons. The recent changes in European and Dutch legislation on medical research were another reason to start this guideline project. We conducted two systematic reviews (on informed consent and recruitment) and conducted surveys and focus groups on the other four topics covered by the paper: proportionality, resistance, drop out, and societal relevance. In total we formulated 45 recommendations, all agreed on in consensus meetings, in which older persons' representatives played a major role. This Guideline on med...Continue Reading

References

Nov 7, 2002·Archives of Internal Medicine·Jennifer L WolffGerard Anderson
Aug 4, 2004·Lancet·Jako S Burgers, Jannes J E van Everdingen
Dec 31, 2004·The New England Journal of Medicine·Mary E TinettiJoseph V Agostini
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Oct 1, 2013·Expert Opinion on Drug Safety·Robert L MaherEmily R Hajjar
Mar 28, 2017·PloS One·Floor J van DeudekomSimon P Mooijaart

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Citations

Nov 11, 2017·Tijdschrift voor gerontologie en geriatrie·Barbara van Munster
Nov 10, 2017·Tijdschrift voor gerontologie en geriatrie·Marleen HemsYvonne Schoon
May 30, 2020·BMC Geriatrics·Lotte M BarmentlooSuzanne Polinder

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