Guidelines following hydatidiform mole: a reappraisal

The Australian & New Zealand Journal of Obstetrics & Gynaecology
Linda KerkmeijerMichael Quinn

Abstract

The aim of this study was to determine how often patients with complete hydatidiform mole (CHM) who spontaneously achieve normal human chorionic gonadotrophin (hCG) levels subsequently develop persistent or recurrent gestational trophoblast disease. Four hundred and fourteen cases of CHM registered at the Hydatidiform Mole Registry of Victoria were reviewed retrospectively after molar evacuation. Maternal age, gestational age, gravidity and parity were determined for each patient, as well as the need for chemotherapy. Among the 414 patients, 55 (13.3%) required chemotherapy for persistent trophoblastic disease. None of the patients whose hCG levels spontaneously fell to normal subsequently developed persistent molar disease. Weekly hCG measurements are recommended for all patients until normal levels are achieved. For patients who attain normal hCG levels within 2 months after evacuation, it seems safe to discontinue monitoring once normal levels are achieved. Patients who fail to achieve normal hCG levels by 2 months after evacuation should be monitored with monthly hCG measurements for 1 year after normalisation to assure sustained remission.

References

Sep 20, 1986·Lancet·K D BagshaweJ Webb
Feb 1, 1985·The Australian & New Zealand Journal of Obstetrics & Gynaecology·G OlesnickyB L Kneale
May 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·K D BagshaweA Kardana
Mar 1, 1983·American Journal of Obstetrics and Gynecology·J R LurainB Halpern
Jun 20, 1998·Journal of Paediatrics and Child Health·M M RileyJ M Lumley
Sep 14, 2000·Gynecologic Oncology·P C LoriganB W Hancock
Nov 21, 2000·Obstetrics and Gynecology·L S MassadV Renta
Apr 10, 2003·Obstetrics and Gynecology·Colleen M FeltmateRoss S Berkowitz
Dec 23, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jozsef BatorfiVilmos Fulop
Sep 2, 2004·Obstetrics and Gynecology·Adam J WolfbergEllice Lieberman
Apr 28, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Sabien WielsmaMichael Quinn

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Citations

Apr 17, 2009·The New England Journal of Medicine·Ross S Berkowitz, Donald P Goldstein
Aug 20, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Angiolo GadducciStefania Cosio
Aug 1, 2012·Gynecologic Oncology·Ross S Berkowitz, Donald Peter Goldstein
Aug 3, 2010·Lancet·Michael J SecklRoss S Berkowitz
Mar 29, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·M GueyeJ C Moreau
Oct 26, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hirokazu UsuiMakio Shozu
Oct 10, 2020·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Gaithri MylvaganamTrevor Tejada-Berges

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