Guidelines for diagnosing and treating pulmonary infiltrates in children with acute leukaemia: impact of timely decisions

Acta Paediatrica
M E Y FuruyaG Zúñiga-Vázquez

Abstract

Children with leukaemia are at increased risk of pulmonary complications, often with unspecific clinical data, delayed diagnosis and a high mortality rate. We evaluated the usefulness of diagnostic-therapeutic guidelines (DTG) in which specific times for decision making were incorporated. Clinical charts of children with acute leukaemia and suspicion of pulmonary involvement were reviewed. Patients were allocated to group I if their diagnostic and therapeutic decisions were in accordance with the DTG, and to group II if not. Children from group I (n=32) and group II (n=28) did not differ with respect to age (9.3+/-0.5 years old, mean+/-SEM), gender, type, risk and stage of leukaemia, anaemia and neutropenia. Total length of hospital stay and hospitalization due to the pulmonary disease were shorter in group I than in group II (14.8+/-2.1 vs. 28.5+/-3.7 days, p=0.0016; and 10.8+/-1.0 vs. 18.4+/-1.8 days, p=0.0003, respectively). Two patients (6.3%) died due to the pulmonary pathology in group I, and nine (32.1%, p=0.016) in group II. Diagnostic-therapeutic guidelines that incorporate timely decisions constitute a useful algorithm to reduce the length of hospital stay and mortality in children with acute leukaemia and pulmonary i...Continue Reading

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Citations

Feb 11, 2012·Journal of Pediatric Hematology/oncology·M E Y FuruyaAlicia Rodríguez-Velasco
Jan 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·DeepakBabu ChellapandianLillian Sung

Related Concepts

Lung Diseases
Acute Myeloid Leukemia, M1
Leukemia, Lymphocytic, Acute, L2
Anemia
Cessation of Life
Decision Making
Diagnosis
Hospitalization
Leukemia
Lung

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