Guidelines for pre-clinical assessment of the acetylcholine receptor--specific passive transfer myasthenia gravis model-Recommendations for methods and experimental designs

Experimental Neurology
Linda L KusnerPilar Martínez-Martínez

Abstract

Antibodies against the muscle acetylcholine receptor (AChR) are the most common cause of myasthenia gravis (MG). Passive transfer of AChR antibodies from MG patients into animals reproduces key features of human disease, including antigenic modulation of the AChR, complement-mediated damage of the neuromuscular junction, and muscle weakness. Similarly, AChR antibodies generated by active immunization in experimental autoimmune MG models can subsequently be passively transferred to other animals and induce weakness. The passive transfer model is useful to test therapeutic strategies aimed at the effector mechanism of the autoantibodies. Here we summarize published and unpublished experience using the AChR passive transfer MG model in mice, rats and rhesus monkeys, and give recommendations for the design of preclinical studies in order to facilitate translation of positive and negative results to improve MG therapies.

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Citations

Jul 14, 2016·F1000Research·William D Phillips, Angela Vincent
Jan 23, 2018·Annals of the New York Academy of Sciences·Linda L KusnerHenry J Kaminski
Mar 3, 2020·Frontiers in Neurology·Maria Pia GiannoccaroAngela Vincent
Mar 11, 2020·Frontiers in Immunology·Ruksana Huda
Jun 26, 2020·Frontiers in Immunology·Khaled AlbazliJames F Howard
Aug 8, 2021·International Journal of Molecular Sciences·Shama R IyerRichard M Lovering

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