Guidelines for safe handling of hazardous drugs: A systematic review

PloS One
Mari A Bernabeu-MartínezJavier Sanz-Valero

Abstract

To review the scientific literature related to the safe handling of hazardous drugs (HDs). Critical analysis of works retrieved from MEDLINE, the Cochrane Library, Scopus, CINHAL, Web of Science and LILACS using the terms "Hazardous Substances", "Antineoplastic Agents" and "Cytostatic Agents", applying "Humans" and "Guidelines" as filters. Date of search: January 2017. In total, 1100 references were retrieved, and from those, 61 documents were selected based on the inclusion and exclusion criteria: 24 (39.3%) documents related to recommendations about HDs; 27 (44.3%) about antineoplastic agents, and 10 (33.3%) about other types of substances (monoclonal antibodies, gene medicine and other chemical and biological agents). In 14 (23.3%) guides, all the stages in the manipulation process involving a risk due to exposure were considered. Only one guide addressed all stages of the handling process of HDs (including stages with and without the risk of exposure). The most described stages were drug preparation (41 guides, 67.2%), staff training and/or patient education (38 guides, 62.3%), and administration (37 guides, 60.7%). No standardized informatics system was found that ensured quality management, traceability and minimization o...Continue Reading

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Citations

Aug 30, 2018·Journal of Medical Systems·Mateo Ramos-MerinoJavier Sanz-Valero
Nov 7, 2019·Nutrients·Alicia Gea CabreraElsa López-Pintor
Jun 25, 2020·Revista brasileira de enfermagem·João Marcos Alves MeloAndrea Bezerra Rodrigues
Oct 18, 2020·International Urogynecology Journal·Ana Isabel López-LópezMaria Pastor-Valero
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May 6, 2021·Revista brasileira de enfermagem·Rosilene Aparecida Costa AmaralKelli Borges Dos Santos
Jul 3, 2021·Pharmaceuticals·M Francisca Portilha-CunhaMónica S F Santos
Jul 8, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Galit Levin, Paul Jm Sessink
Aug 29, 2021·Pharmaceuticals·Maria Francisca Portilha-CunhaMónica S F Santos
Nov 4, 2021·BMC Health Services Research·María Carmen Carnero, Andrés Gómez
Nov 19, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Moataz M HassanIbrahim Al-Zakwani

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