Guidelines for the clinical management of familial adenomatous polyposis (FAP)

Gut
H F A VasenJ Wijnen

Abstract

Familial adenomatous polyposis (FAP) is a well-described inherited syndrome, which is responsible for <1% of all colorectal cancer (CRC) cases. The syndrome is characterised by the development of hundreds to thousands of adenomas in the colorectum. Almost all patients will develop CRC if they are not identified and treated at an early stage. The syndrome is inherited as an autosomal dominant trait and caused by mutations in the APC gene. Recently, a second gene has been identified that also gives rise to colonic adenomatous polyposis, although the phenotype is less severe than typical FAP. The gene is the MUTYH gene and the inheritance is autosomal recessive. In April 2006 and February 2007, a workshop was organised in Mallorca by European experts on hereditary gastrointestinal cancer aiming to establish guidelines for the clinical management of FAP and to initiate collaborative studies. Thirty-one experts from nine European countries participated in these workshops. Prior to the meeting, various participants examined the most important management issues according to the latest publications. A systematic literature search using Pubmed and reference lists of retrieved articles, and manual searches of relevant articles, was perfo...Continue Reading

Citations

Aug 2, 2012·JAMA : the Journal of the American Medical Association·Shilpa GroverSapna Syngal
Feb 23, 2010·Diseases of the Colon and Rectum·Myles JoyceJames Church
Jul 16, 2010·Diseases of the Colon and Rectum·Florentia FostiraDrakoulis Yannoukakos
Dec 24, 2010·Diseases of the Colon and Rectum·Riccardo NascimbeniBruno Salerni
Jun 10, 2011·Diseases of the Colon and Rectum·Kaisa FritzellLena Wettergren
Jan 15, 2009·European Journal of Nutrition·Kari AlmendingenMorten Harald Vatn
Dec 8, 2010·Surgical Endoscopy·Marco VitellaroLucio Bertario
Nov 26, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Tomohiro YamaguchiYoshihiro Moriya
Jul 3, 2013·Best Practice & Research. Clinical Gastroenterology·Robert M Genta, Linda A Feagins
Feb 15, 2012·Gastroenterología y hepatología·Francesc Balaguer Prunés
Oct 8, 2009·European Journal of Human Genetics : EJHG·Kirsten F L DoumaEveline M A Bleiker
Mar 4, 2011·European Journal of Human Genetics : EJHG·Stefan AretzSylviane Olschwang
Jul 10, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H F A VasenUNKNOWN ESMO Guidelines Working Group
Jul 3, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J BalmañaUNKNOWN ESMO Guidelines Working Group
Dec 6, 2011·European Journal of Public Health·Benedetto SimoneStefania Boccia
Aug 15, 2012·Current Opinion in Pediatrics·Kalpesh ThakkarMark A Gilger
Feb 10, 2010·Cancer Nursing·Kaisa FritzellLena Wettergren
Jul 17, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K F L DoumaH F A Vasen
Jun 10, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A SinhaS K Clark
Nov 23, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S Bülow
Jun 22, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F J McNicolS K Clark
Apr 4, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M CasperJ Raedle
Jun 16, 2012·Sarcoma·George T CalvertR Lor Randall
Oct 14, 2009·Orphanet Journal of Rare Diseases·Elizabeth HalfPaul Rozen
Apr 9, 2013·Orphanet Journal of Rare Diseases·Giovana Tardin TorrezanDirce Maria Carraro
Aug 9, 2011·Hereditary Cancer in Clinical Practice·Evgeny N Imyanitov, Vladimir M Moiseyenko
Mar 25, 2010·World Journal of Gastroenterology : WJG·Jian-Qiu ShengShi-Rong Li
Feb 26, 2014·Hereditary Cancer in Clinical Practice·Saowanee NgamruengphongDouglas L Riegert-Johnson
Apr 23, 2013·Surgery Today·Satoru YamaguchiHiroyuki Kato
Dec 3, 2013·International Journal of Colorectal Disease·L KoskenvuoA Lepistö
Sep 15, 2012·Techniques in Coloproctology·M Ponz de LeonT Venesio
Jan 8, 2014·The American Journal of Gastroenterology·Miriam RomeroSuzanne L Palmer
Jul 10, 2012·Surgical Endoscopy·Emanuele D L UrsoDonato Nitti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.