Guidelines for using quantitative measures of brain magnetic resonance imaging abnormalities in monitoring the treatment of multiple sclerosis

Annals of Neurology
M FilippiD H Miller

Abstract

The change of brain lesion load, measured on T2-weighted magnetic resonance imaging (MRI) using computer-assisted techniques, is a widely used secondary endpoint for phase III clinical trials in multiple sclerosis (MS). Collection, transfer, and analysis of the electronic data across multiple centers have all proved challenging and give rise to potential errors. However, many new acquisition schemes and postprocessing techniques have been developed; these may reduce scan times and result in better lesion conspicuity or lessen the human interaction needed for data analysis. This review considers many aspects of the use of MRI in clinical trials for MS and provides international consensus guidelines, derived from a task force of the European Magnetic Resonance Networks in Multiple Sclerosis (MAGNIMS) together with a group of North American experts. The main points considered are the organization of correctly powered trials and selection of participating sites; the appropriate choice of pulse sequences and image acquisition protocol given the current state of technology; quality assurance for data acquisition and analysis; accuracy and reproducibility of lesion load assessments; and the potential for the application of quantitativ...Continue Reading

References

Jan 1, 1977·British Medical Bulletin·C W Adams
Nov 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R T Constable, J C Gore
May 1, 1991·Journal of Magnetic Resonance Imaging : JMRI·P S MelkiF A Jolesz
Aug 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·D H MillerA J Thompson
Dec 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J HennigH Friedburg
Jan 1, 1995·Duodecim; lääketieteellinen aikakauskirja·M PaneliusJ Ruutiainen
Sep 1, 1996·Journal of Magnetic Resonance Imaging : JMRI·M L Gawne-CainD H Miller
Oct 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M A van BuchemR I Grossman
Dec 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·M FilippiR Voltz
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B J BedellJ S Wolinsky
Dec 1, 1996·Brain : a Journal of Neurology·N A LosseffA J Thompson
Mar 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·T KoudriavtsevaC Pozzilli
Apr 1, 1997·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·M FilippiG Comi

❮ Previous
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Citations

Feb 12, 2002·Journal of Magnetic Resonance Imaging : JMRI·Xingchang WeiCharles R G Guttmann
Oct 9, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D Goldberg-ZimringA Achiron
Dec 25, 2012·Journal of Neurology·Maria A RoccaMassimo Filippi
Jul 16, 2009·Journal of Digital Imaging·G LuccichentiS Bastianello
Apr 9, 2002·Current Neurology and Neuroscience Reports·Massimo FilippiMarco Rovaris
Nov 11, 2003·Journal of the Neurological Sciences·M A HorsfieldR Bakshi
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Dominik S MeierCharles R G Guttmann
Jun 24, 2000·Journal of the Neurological Sciences·M FilippiG Comi
Dec 22, 1999·Journal of the Neurological Sciences·M Rovaris, M Filippi
Jul 20, 2002·Clinical Neurology and Neurosurgery·David H Miller
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D H Miller, A J Thompson
Apr 12, 2001·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·R BakshiL Jacobs
Oct 17, 2002·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Massimo FilippiMarco Rovaris
Apr 14, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·M P SormaniM Filippi
Jan 25, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·M FilippiG Comi
Feb 22, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·M CercignaniM Filippi
Jul 31, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Tadeusz W StadnikMichel J Osteaux
Oct 13, 2006·Neuroimmunomodulation·Carlos O BrandãoLeonilda M B Santos
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Rohit BakshiJerry S Wolinsky
Jul 31, 2003·Drugs·Peter Flachenecker, Peter Rieckmann
Mar 24, 2010·Radiology·Bastiaan MoraalFrederik Barkhof
Nov 28, 2008·Radiology·Bastiaan MoraalFrederik Barkhof
May 30, 2008·European Radiology·Bastiaan MoraalFrederik Barkhof
Jul 6, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Massimo FilippiNicola De Stefano
May 24, 2011·Radiology·Massimo Filippi, Maria A Rocca
May 25, 2012·The British Journal of Radiology·P S Tofts, D J Collins
May 9, 2002·Journal of Magnetic Resonance Imaging : JMRI·I Leng TanFrederik Barkhof
Dec 11, 2008·Neuroimaging Clinics of North America·Mark A Horsfield
Nov 4, 2015·Nature Reviews. Neurology·Christian EnzingerUNKNOWN MAGNIMS study group
Apr 29, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M FilippiJ S Wolinsky
Apr 12, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Massimo Filippi, Maria A Rocca
Apr 12, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Maria Pia Sormani, Massimo Filippi
Apr 12, 2007·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Franz FazekasMassimo Filippi
Apr 24, 2010·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Ronald AntulovRobert Zivadinov
Aug 20, 2005·Journal of the Neurological Sciences·Xia LinCris S Constantinescu

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