Guidelines of treatment for bleeding peptic ulcer disease

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Il Kwun ChungKorean Association of Gastroenterology

Abstract

Peptic ulcer (PU) bleeding is the main cause of non-variceal gastrointestinal bleeding. Negative outcomes include re-bleeding and death, and many of the deaths are associated with decompensation of coexisting medical conditions precipitated by acute bleeding event. Accurate analysis of risk for clinical features can help physician to decide treatment modality. Endoscopy can detect bleeding stigmata and perform therapeutic hemostasis. Proton pump inhibitor (PPI) compared with placebo or H2RA reduces mortality following PU bleeding among patients with high-risk endoscopic findings, and reduces re-bleeding rates and surgical intervention. PPI treatment initiated prior to endoscopy in upper gastrointestinal (UGI) bleeding significantly reduces the proportion of patients with stigmata of recent hemorrhage (SRH) at index endoscopy but does not reduce mortality, re-bleeding or the need for surgery. The strategy of giving oral PPI before and after endoscopy, with endoscopic hemostasis for those with major SRH, is likely to be the most cost-effective. The treatment of H. pylori infection was found to be more effective than anti-secretory therapy in preventing recurrent bleeding from PU. H. pylori eradication alone and eradication follow...Continue Reading

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Jul 25, 2012·World Journal of Gastroenterology : WJG·Young Hoon YounHyojin Park
Nov 5, 2014·Journal of Korean Medical Science·Mi Jin HongChoon Jo Jin
Dec 14, 2017·The Korean Journal of Internal Medicine·Su Sun KimWoon Geon Shin
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Mar 6, 2015·World Journal of Gastroenterology : WJG·Hyuk YoonNayoung Kim
Jun 26, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Joon Sung KimSaebeom Hur
Sep 15, 2020·Gut and Liver·Joon Sung KimSaebeom Hur
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Nov 17, 2020·Gut and Liver·Moon Kyung JooUNKNOWN Korean College of Helicobacter Upper Gastrointestinal Research
Nov 26, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Moon Kyung Joo
Nov 26, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hyo-Joon Yang

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